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Income Taxes - Statutory Rate (Details) - USD ($)		12 Months Ended
	Dec. 22, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income (loss) before income taxes:
United States		$ (309,183,000)	$ (440,696,000)	$ (174,913,000)
Foreign		(39,906,000)	(8,425,000)	(28,868,000)
Loss before income tax		(349,089,000)	(449,121,000)	(203,781,000)
Current
Federal		0	0	0
State		6,000	9,000	7,000
Foreign		(100,000)	2,276,000	0
Deferred
Federal		0	(150,015,000)	(1,101,000)
State		0	(17,389,000)	(2,645,000)
Foreign		0	0	0
Total		$ (94,000)	$ (165,119,000)	$ (3,739,000)
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate	(21.00%)	(21.00%)	(34.00%)	(34.00%)
State taxes, net of federal benefit		(4.00%)	(5.00%)	(5.00%)
Nondeductible IPR&D		6.00%	(1.00%)	3.00%
Contingent consideration		1.00%	(18.00%)	(0.00%)
Tax credits		(10.00%)	(2.00%)	(3.00%)
Foreign income tax rate differential		2.00%	5.00%	2.00%
Impact of 2017 Act		(0.00%)	27.00%	(0.00%)
Other		(0.00%)	5.00%	(1.00%)
Valuation allowance		26.00%	(14.00%)	36.00%
Net		(0.00%)	(37.00%)	(2.00%)
Income tax benefit		$ (94,000)	$ (165,119,000)	$ (3,739,000)
Foreign and state income tax expense (benefits)		(100,000)
Accrual for interest and penalties		0
Accrual for uncertain tax positions		$ 0

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Name:	us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterestAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

The portion of earnings or loss from continuing operations before income taxes that is attributable to foreign operations, which is defined as Income or Loss generated from operations located outside the entity's country of domicile.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(h)(1)(i))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

+ Details

Name:	us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign
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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (h)
-URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 20
-Section 45
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109238882&loc=d3e38679-109324

+ Details

Name:	us-gaap_IncomeTaxExpenseBenefit
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount recognized for uncertainty in income taxes classified as current.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.20)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

+ Details

Name:	us-gaap_LiabilityForUncertainTaxPositionsCurrent
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Balance Type:	credit
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X

- Definition

Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319

+ Details

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Data Type:	xbrli:monetaryItemType
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Period Type:	instant