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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Deferred tax assets
Intellectual property	$ 48,339	$ 44,573
Amortization/depreciation	3,732	3,082
Research tax credit	96,509	43,382
Net operating loss carry forwards	248,398	221,912
Deferred revenue	4,401	6,158
Non-cash stock issue	16,850	10,751
Interest carry forward limitation	1,032	0
Others	10,852	7,328
Gross deferred tax assets	430,113	337,186
Deferred tax liabilities
Business acquisition	(6,465)	(6,465)
Royalty payable	(48,339)	(44,573)
Convertible notes	(16,666)	(18,991)
Advanced R&D payments	(2,103)	(3,069)
Total net deferred tax assets	356,540	264,088
Less: valuation allowance	(363,005)	(270,553)
Net deferred tax liability	(6,465)	$ (6,465)
Increase in the valuation allowance	$ (92,400)

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