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Income Taxes - Loss Carryforwards (Details) $ in Millions	Dec. 31, 2018 USD ($)
Research and experimentation tax credit carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	$ 23.7
Orphan drug tax credit carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	72.8
Federal
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	858.4
State
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	943.5
Foreign
Operating Loss Carryforwards [Line Items]
Amount of net operating loss carry forwards	$ 35.0

X

- Definition

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
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