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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance at Dec. 31, 2015 $ 347,834 $ 1,306 $ 917,454 $ 8,755 $ (115) $ (579,566)
Balance (in shares) at Dec. 31, 2015   125,027,034        
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net 3,036 $ 7 3,029      
Stock issued from exercise of stock options, net (in shares)   723,102        
Stock issued from ATM transactions 97,068 $ 150 96,918      
Stock issued from ATM transactions (in shares)   14,989,027        
Stock issued for MiaMed acquisition 4,607 $ 8 4,599      
Stock issued for MiaMed acquisition (in shares)   825,603        
Restricted stock tax vesting (1,282)   (1,282)      
Restricted stock tax vesting (in shares)   268,425        
Stock issued for contingent consideration 6,115 $ 9 6,106      
Stock issued for contingent consideration (in shares)   858,795        
Receivable from investor 932   932      
Warrants issued in debt financing 7,321     7,321    
Equity component of the Convertible Notes issuance, net of issuance costs of $2,709 88,346   88,346      
Premium paid for Capped Call Confirmations (13,450)   (13,450)      
Stock-based compensation 17,504   17,504      
Unrealized holding gain on available-for-sale securities 217       217  
Foreign currency translation adjustment 1,945       1,945  
Net loss (200,042)         (200,042)
Balance at Dec. 31, 2016 360,151 $ 1,480 1,120,156 16,076 2,047 (779,608)
Balance (in shares) at Dec. 31, 2016   142,691,986        
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net 16,301 $ 29 16,272      
Stock issued from exercise of stock options, net (in shares)   2,878,681        
Stock issued from equity financing 243,037 $ 212 242,825      
Stock issued from equity financing (in shares)   21,122,449        
Restricted stock tax vesting (1,596)   (1,596)      
Restricted stock tax vesting (in shares)   296,674        
Stock-based compensation 23,101   23,101      
Unrealized holding gain on available-for-sale securities (538)       (538)  
Foreign currency translation adjustment (3,604)       (3,604)  
Net loss (284,002)         (284,002)
Balance at Dec. 31, 2017 $ 352,850 $ 1,721 1,400,758 16,076 (2,095) (1,063,610)
Balance (in shares) at Dec. 31, 2017 166,989,790 166,989,790        
Increase (Decrease) in Stockholders' Equity            
Reclassification upon ASU 2018-02 adoption $ 0       (383) 383
Stock issued from exercise of stock options, net 9,144 $ 14 9,130      
Stock issued from exercise of stock options, net (in shares)   1,397,908        
Stock issued from equity financing 294,583 $ 202 294,381      
Stock issued from equity financing (in shares)   20,239,839        
Restricted stock tax vesting (2,832)   (2,832)      
Restricted stock tax vesting (in shares)   303,173        
Stock-based compensation 29,260   29,260      
Unrealized holding gain on available-for-sale securities 9       9  
Foreign currency translation adjustment 2,537       2,537  
Net loss (348,995)         (348,995)
Warrants exercised 3,617 $ 5 6,625 (3,013)    
Warrants exercised (in shares)   453,214        
Change in fair value of derivatives 2,739   2,739      
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 $ 1,740,061 $ 13,063 $ 68 $ (1,412,222)
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924