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v3.19.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Operating activities |  |
Net loss | $ (120,299) | $ (49,916)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Amortization of debt discount and deferred financing | 1,649 | 2,601
Depreciation and amortization | 991 | 969
Stock-based compensation | 12,744 | 7,478
Loss on exchange of convertible debt | 36,123 | 0
Change in fair value of derivatives | 0 | (4,861)
Non-cash changes in the fair value of contingent consideration payable | 1,383 | 1,100
Foreign currency remeasurement (gain) loss | 325 | (2,957)
Changes in operating assets and liabilities: |  |
Accounts receivable | (1,001) | (1,047)
Inventories | 345 | (3,253)
Prepaid expenses and other current assets | 3,059 | 10,875
Accounts payable and accrued expenses | (8,858) | (10,347)
Other non-current assets and liabilities | (3,507) | (163)
Deferred reimbursements | (1,500) | 0
Net cash used in operating activities | (78,546) | (49,521)
Investing activities |  |
Sale and redemption of marketable securities | 135,187 | 121,226
Purchases of marketable securities | (52,178) | (303,010)
Capital expenditures | (2,944) | (819)
Net cash used in investing activities | 80,065 | (182,603)
Financing activities |  |
Proceeds from issuance of common stock, net of issuance costs | 0 | 294,584
Payment of finance leases | (75) |
Payment of finance leases |  | (71)
Purchase of vested restricted stock units | (1,938) | (1,912)
Proceeds from termination of capped call confirmations | 14,632 | 0
Proceeds from exercise of stock options | 3,953 | 3,978
Proceeds of exercise of warrants | 812 | 0
Net cash provided by financing activities | 17,384 | 296,579
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (2,350) | 860
Net decrease in cash, cash equivalents and restricted cash | 16,553 | 65,315
Cash, cash equivalents and restricted cash at beginning of period | 82,375 | 51,237
Cash, cash equivalents and restricted cash at end of period | 98,928 | 116,552
Cash paid during the period for interest |  |
Capital expenditures, unpaid | 4,846 | 12
Capital expenditures, unpaid | 0 | 142
Payment of contingent consideration in shares | $ 9,316 | $ 0

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