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Business (Details) $ / shares in Units, $ in Thousands, shares in Millions | Mar. 31, 2019 USD ($) program $ / shares shares | Dec. 31, 2018 USD ($) $ / shares
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Organization, Consolidation and Presentation of Financial Statements [Abstract] |  |
Number of gene therapy programs | program | 14 |
Exchange agreement, aggregate principal amount | $ 219,300 |
Shares authorized for issuance (in shares) | shares | 39.0 |
Common stock, par value (in dollars per share) | $ / shares | $ 0.01 | $ 0.01
Accumulated deficit | $ (1,532,521) | $ (1,412,222)

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