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Stockholders' Equity - Common Stock and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 3 Months Ended |
--- | --- | --- | --- | ---
Feb. 16, 2018 | Feb. 15, 2018 | Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018
Collaborative Agreements |  |  |  |  |
Proceeds of exercise of warrants |  |  | $ 812 | $ 0 |
Exchange agreement, aggregate principal amount |  |  | $ 219,300 |  |
Shares authorized for issuance (in shares) |  |  | 39,000,000 |  |
Common stock, par value (in dollars per share) |  |  | $ 0.01 |  | $ 0.01
Contingent consideration, milestone payment |  |  | $ 9,000 |  |
Milestone payment, stock issued as consideration |  |  | $ 9,000 |  |
Common Stock |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Common stock issued from underwriting agreement (in shares) |  |  | 301,058 | 181,868 |
Milestone payment, stock issued as consideration |  |  | $ (9,300) |  |
Common Stock |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Common stock issued from underwriting agreement (in shares) | 885,000 | 19,354,839 |  |  |
Outstanding warrants, convertible to common stock |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Common stock issued from underwriting agreement (in shares) |  |  | 101,787 |  |
Proceeds of exercise of warrants |  |  | $ 800 |  |
Outstanding warrants, convertible to common stock | Common Stock |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Warrants exercise price (in dollars per share) |  |  | $ 7.98 |  |

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