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Share based Compensation (Tables)

3 Months Ended

Mar. 31, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Schedule of Fair Value of Options

The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:

	Three Months Ended March 31,
	2019				2018
Expected stock price volatility	74.2		%		81.2		%
Risk free interest rate	2.5		%		2.3		%
Expected life of options (years)	5.68				5.67
Expected annual dividend per share	$	—			$	—

Schedule of Stock Options Activity

A summary of the Company's stock options for the three months ended March 31, 2019 were as follows:

	Number of Shares			Weighted Average Exercise Price				Weighted Average Remaining Contractual Life		Aggregate Intrinsic Value
	(in thousands)									(in millions)
Options outstanding, December 31, 2018	15,810			$	8.63
Granted	3,315			$	10.15
Exercised	(578	)		$	6.83
Forfeited	(195	)		$	10.33
Expired	(21	)		$	10.77
Options outstanding, March 31, 2019	18,331			$	8.94			6.9 years		$	90.2
Vested and unvested expected to vest, March 31, 2019	17,325			$	8.84			6.8 years		$	87.1
Exercisable at March 31, 2019	10,538			$	7.84			5.5 years		$	62.8

Schedule of Non-Vested RSU Activity under the Plan

A summary of non-vested RSU activity under the Plan for the three months ended March 31, 2019 is as follows:

	Number of Shares			Weighted Average Grant Date Fair Value				Weighted Average Remaining Years		Aggregate Intrinsic Value
	(in thousands)									(in millions)
Non-vested units as of December 31, 2018	3,712			$	10.59
Granted	3,031			$	10.91
Vested	(600	)		$	9.07
Forfeited	(133	)		$	12.73
Non-vested units as of March 31, 2019	6,010			$	10.86			3.0 years		$	81.7

Schedule of Equity Compensation Expenses

The following table summarizes information related to compensation expense recognized in the statements of operations related to the equity awards:

		Three Months Ended March 31,
(in thousands)		2019				2018
Equity compensation expense recognized in:
Research and development expense		$	5,032			$	3,057
Selling, general and administrative expense		7,712				4,421
Total equity compensation expense		$	12,744			$	7,478

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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