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Stockholders' Equity - Common Stock and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended
	Feb. 16, 2018	Feb. 15, 2018	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018
Collaborative Agreements
Proceeds of exercise of warrants			$ 812	$ 0
Exchange agreement, aggregate principal amount			$ 219,300
Shares authorized for issuance (in shares)			39,000,000
Common stock, par value (in dollars per share)			$ 0.01		$ 0.01
Contingent consideration, milestone payment			$ 9,000
Milestone payment, stock issued as consideration			$ 9,000
Common Stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)			301,058	181,868
Milestone payment, stock issued as consideration			$ (9,300)
Common Stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)	885,000	19,354,839
Outstanding warrants, convertible to common stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)			101,787
Proceeds of exercise of warrants			$ 800
Outstanding warrants, convertible to common stock | Common Stock
Collaborative Agreements
Warrants exercise price (in dollars per share)			$ 7.98

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