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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenue:    
Net product sales $ 34,046 $ 16,696
Cost of goods sold 4,055 2,615
Gross profit 29,991 14,081
Operating expenses:    
Research and development 64,593 40,798
Selling, general and administrative 44,303 27,396
Changes in fair value of contingent consideration payable 1,383 1,100
Depreciation and amortization 991 969
Total operating expenses 111,270 70,263
Loss from operations (81,279) (56,182)
Other income (expense):    
Interest income 2,639 1,737
Interest expense (6,454) (4,488)
Loss on exchange of convertible notes (36,123) 0
Change in fair value of derivatives 0 4,861
Other (expense) income 1,086 2,764
Loss before income tax (120,131) (51,308)
Income tax benefit (168) 1,392
Net loss attributable to common stockholders $ (120,299) $ (49,916)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (0.56) $ (0.28)
Weighted-average common shares outstanding - basic and diluted (in shares) 213,519,287 175,977,700