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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Outstanding warrants, convertible to common stock
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance at Dec. 31, 2017 $ 352,850 $ 1,721 $ 1,400,758 $ 16,076 $ (2,095) $ (1,063,610)
Balance (in shares) at Dec. 31, 2017   166,989,790        
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net 3,978 $ 6 3,972      
Stock issued from exercise of stock options, net (in shares)   560,721        
Stock issued from equity financing 294,584 $ 202 294,382      
Stock issued from equity financing (in shares)   20,239,839        
Restricted stock tax vesting (1,912)   (1,912)      
Restricted stock tax vesting (in shares)   181,868        
Stock issued for contingent consideration 0 $ 0 0      
Stock issued for contingent consideration (in shares)   0        
Stock-based compensation 7,478   7,478      
Change in fair value of derivatives (83,199)   (83,199)      
Unrealized holding gain on available-for-sale securities (441)       (441)  
Foreign currency translation adjustment (1,805)       (1,805)  
Net loss (49,916)         (49,916)
Balance at Mar. 31, 2018 521,617 $ 1,929 1,621,479 16,076 (4,724) (1,113,143)
Balance (in shares) at Mar. 31, 2018   187,972,218        
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 1,740,061 13,063 68 (1,412,222)
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924        
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net $ 3,953 $ 6 3,947      
Stock issued from exercise of stock options, net (in shares)   578,451        
Restricted stock tax vesting (1,940) $ 0 (1,940)      
Restricted stock tax vesting (in shares)   301,058        
Stock issued for contingent consideration 9,316 $ 8 9,308      
Stock issued for contingent consideration (in shares)   771,804        
Stock-based compensation 12,744   12,744      
Warrants exercised 812 $ 1 1,487 (676)    
Warrants exercised (in shares)   101,787        
Equity component of the convertible notes 190,758 $ 390 190,368      
Equity component of the convertible notes (in shares)   39,043,690        
Termination of capped call confirmations 14,632   14,632      
Unrealized holding gain on available-for-sale securities 584       584  
Foreign currency translation adjustment (1,804)       (1,804)  
Net loss (120,299)         (120,299)
Balance at Mar. 31, 2019 $ 451,668 $ 2,347 $ 1,970,607 $ 12,387 $ (1,152) $ (1,532,521)
Balance (in shares) at Mar. 31, 2019 230,180,714 230,180,714