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v3.19.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2019 | Jun. 30, 2018
Operating activities |  |
Net loss | $ (204,850) | $ (111,751)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Amortization of debt discount and deferred financing | 2,104 | 5,273
Depreciation and amortization | 2,145 | 1,942
Stock-based compensation | 22,679 | 13,819
Loss on exchange of convertible debt | 40,624 | 0
Change in fair value of derivatives | 0 | 2,739
Non-cash changes in the fair value of contingent consideration payable | 1,863 | 1,400
Foreign currency remeasurement loss | 530 | 2,107
Changes in operating assets and liabilities: |  |
Accounts receivable | (6,829) | (6,043)
Inventories | (1,908) | (3,449)
Prepaid expenses and other current assets | (3,523) | 4,584
Accounts payable and accrued expenses | 12,453 | (11,801)
Other non-current assets and liabilities | (819) | (336)
Deferred reimbursements | (1,500) | (5,000)
Net cash used in operating activities | (137,031) | (106,516)
Investing activities |  |
Sale and redemption of marketable securities | 261,425 | 210,239
Purchases of marketable securities | (191,318) | (380,234)
Capital expenditures | (5,110) | (1,881)
Net cash provided by (used in) investing activities | 64,997 | (171,876)
Financing activities |  |
Proceeds from issuance of common stock, net of issuance costs | 188,994 | 294,584
Payment of finance leases | (98) |
Payment of finance leases |  | (142)
Purchase of vested restricted stock units | (2,555) | (2,027)
Proceeds from termination of capped call confirmations | 19,875 | 0
Proceeds from exercise of stock options | 6,760 | 7,580
Proceeds of exercise of warrants | 812 | 3,617
Net cash provided by financing activities | 213,788 | 303,612
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (941) | (1,016)
Net increase in cash, cash equivalents, and restricted cash | 140,813 | 24,204
Cash, cash equivalents, and restricted cash at beginning of period | 82,375 | 51,237
Cash, cash equivalents, and restricted cash at end of period | 223,188 | 75,441
Cash paid during the period for interest |  |
Cash paid during the period for interest | 9,302 | 3,774
Capital expenditures, unpaid | 837 | 0
Capital expenditures funded by capital lease | 0 | 81
Payment of contingent consideration in shares | $ 9,316 | $ 0

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