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Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Outstanding warrants, convertible to common stock | Other Comprehensive Gain (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Reclassification upon ASU 2018-02 adoption | $ 0 |  |  |  | $ (383) | $ 383
Balance (in shares) at Dec. 31, 2017 |  | 166,989,790 |  |  |  |
Balance at Dec. 31, 2017 | 352,850 | $ 1,721 | $ 1,400,758 | $ 16,076 | (2,095) | (1,063,610)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 560,721 |  |  |  |
Stock issued from exercise of stock options, net | 3,978 | $ 6 | 3,972 |  |  |
Stock issued from equity financing (in shares) |  | 20,239,839 |  |  |  |
Stock issued from equity financing | 294,584 | $ 202 | 294,382 |  |  |
Restricted stock tax vesting (in shares) |  | 181,868 |  |  |  |
Restricted stock tax vesting | (1,912) |  | (1,912) |  |  |
Stock-based compensation | 7,478 |  | 7,478 |  |  |
Change in fair value of derivatives | (83,199) |  | (83,199) |  |  |
Unrealized holding gain (loss) on available-for-sale securities | (441) |  |  |  | (441) |
Foreign currency translation adjustment | (1,805) |  |  |  | (1,805) |
Net loss | (49,916) |  |  |  |  | (49,916)
Balance (in shares) at Mar. 31, 2018 |  | 187,972,218 |  |  |  |
Balance at Mar. 31, 2018 | 521,617 | $ 1,929 | 1,621,479 | 16,076 | (4,724) | (1,113,143)
Balance (in shares) at Dec. 31, 2017 |  | 166,989,790 |  |  |  |
Balance at Dec. 31, 2017 | 352,850 | $ 1,721 | 1,400,758 | 16,076 | (2,095) | (1,063,610)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Unrealized holding gain (loss) on available-for-sale securities | (19) |  |  |  |  |
Foreign currency translation adjustment | 503 |  |  |  |  |
Net loss | (111,751) |  |  |  |  |
Balance (in shares) at Jun. 30, 2018 |  | 189,053,214 |  |  |  |
Balance at Jun. 30, 2018 | 561,895 | $ 1,939 | 1,723,865 | 13,063 | (1,994) | (1,174,978)
Balance (in shares) at Mar. 31, 2018 |  | 187,972,218 |  |  |  |
Balance at Mar. 31, 2018 | 521,617 | $ 1,929 | 1,621,479 | 16,076 | (4,724) | (1,113,143)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 542,056 |  |  |  |
Stock issued from exercise of stock options, net | 3,602 | $ 5 | 3,597 |  |  |
Restricted stock tax vesting (in shares) |  | 85,726 |  |  |  |
Restricted stock tax vesting | (115) |  | (115) |  |  |
Stock-based compensation | 6,341 |  | 6,341 |  |  |
Warrants exercised (in shares) |  | 453,214 |  |  |  |
Warrants exercised | 3,617 | $ 5 | 6,625 | (3,013) |  |
Change in fair value of derivatives | 85,938 |  | 85,938 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 422 |  |  |  | 422 |
Foreign currency translation adjustment | 2,308 |  |  |  | 2,308 |
Net loss | (61,833) |  |  |  |  | (61,833)
Balance (in shares) at Jun. 30, 2018 |  | 189,053,214 |  |  |  |
Balance at Jun. 30, 2018 | $ 561,895 | $ 1,939 | 1,723,865 | 13,063 | (1,994) | (1,174,978)
Balance (in shares) at Dec. 31, 2018 | 189,383,924 | 189,383,924 |  |  |  |
Balance at Dec. 31, 2018 | $ 342,912 | $ 1,942 | 1,740,061 | 13,063 | 68 | (1,412,222)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 578,451 |  |  |  |
Stock issued from exercise of stock options, net | 3,953 | $ 6 | 3,947 |  |  |
Restricted stock tax vesting (in shares) |  | 301,058 |  |  |  |
Restricted stock tax vesting | (1,940) |  | (1,940) |  |  |
Stock issued for contingent consideration (in shares) |  | 771,804 |  |  |  |
Stock issued for contingent consideration | 9,316 | $ 8 | 9,308 |  |  |
Stock-based compensation | 12,744 |  | 12,744 |  |  |
Warrants exercised (in shares) |  | 101,787 |  |  |  |
Warrants exercised | 812 | $ 1 | 1,487 | (676) |  |
Equity component of the convertible notes (in shares) |  | 39,043,690 |  |  |  |
Equity component of the convertible notes | 190,758 | $ 390 | 190,368 |  |  |
Termination of capped call confirmations | 14,632 |  | 14,632 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 584 |  |  |  | 584 |
Foreign currency translation adjustment | (1,804) |  |  |  | (1,804) |
Net loss | (120,299) |  |  |  |  | (120,299)
Balance (in shares) at Mar. 31, 2019 |  | 230,180,714 |  |  |  |
Balance at Mar. 31, 2019 | $ 451,668 | $ 2,347 | 1,970,607 | 12,387 | (1,152) | (1,532,521)
Balance (in shares) at Dec. 31, 2018 | 189,383,924 | 189,383,924 |  |  |  |
Balance at Dec. 31, 2018 | $ 342,912 | $ 1,942 | 1,740,061 | 13,063 | 68 | (1,412,222)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 562 |  |  |  |  |
Foreign currency translation adjustment | 77 |  |  |  |  |
Net loss | $ (204,850) |  |  |  |  |
Balance (in shares) at Jun. 30, 2019 | 254,513,522 | 254,513,522 |  |  |  |
Balance at Jun. 30, 2019 | $ 600,058 | $ 2,589 | 2,201,447 | 12,387 | 707 | (1,617,072)
Balance (in shares) at Mar. 31, 2019 |  | 230,180,714 |  |  |  |
Balance at Mar. 31, 2019 | 451,668 | $ 2,347 | 1,970,607 | 12,387 | (1,152) | (1,532,521)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 561,177 |  |  |  |
Stock issued from exercise of stock options, net | $ 2,807 | $ 5 | 2,802 |  |  |
Stock issued from equity financing (in shares) | 18,700,000 | 18,720,930 |  |  |  |
Stock issued from equity financing | $ 188,994 | $ 187 | 188,807 |  |  |
Restricted stock tax vesting (in shares) |  | 99,252 |  |  |  |
Restricted stock tax vesting | (615) |  | (615) |  |  |
Stock-based compensation | 9,935 |  | 9,935 |  |  |
Equity component of the convertible notes (in shares) |  | 4,951,449 |  |  |  |
Equity component of the convertible notes | 24,718 | $ 50 | 24,668 |  |  |
Termination of capped call confirmations | 5,243 |  | 5,243 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | (22) |  |  |  | (22) |
Foreign currency translation adjustment | 1,881 |  |  |  | 1,881 |
Net loss | $ (84,551) |  |  |  |  | (84,551)
Balance (in shares) at Jun. 30, 2019 | 254,513,522 | 254,513,522 |  |  |  |
Balance at Jun. 30, 2019 | $ 600,058 | $ 2,589 | $ 2,201,447 | $ 12,387 | $ 707 | $ (1,617,072)

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