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Summary of Significant Accounting Policies (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Jan. 01, 2019
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Allowance for doubtful accounts receivable $ 200   $ 200    
Net product sales 44,130 $ 21,309 78,176 $ 38,005  
Operating lease, liability 38,937   38,937    
Operating lease ROU asset 35,052   35,052    
ASU 2016-02          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Operating lease, liability         $ 17,600
Operating lease ROU asset 17,600   17,600    
U.S.          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Net product sales 12,181 0 21,249 0  
Ex-U.S.          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Net product sales $ 31,949 $ 21,309 $ 56,927 $ 38,005