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Stockholders' Equity - Common Stock and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended			6 Months Ended
	Feb. 16, 2018	Feb. 15, 2018	Jun. 30, 2019	Mar. 31, 2019	Mar. 31, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)			18,700,000
Proceeds of exercise of warrants						$ 812	$ 3,617
Proceeds from issuance of common stock, net of issuance costs			$ 189,000			188,994	$ 294,584
Exchange agreement, aggregate principal amount			$ 247,200			$ 247,200
Shares authorized for issuance (in shares)			44,000,000.0			44,000,000.0
Common stock, par value (in dollars per share)			$ 0.01			$ 0.01		$ 0.01
Contingent consideration, milestone payment				$ 9,000
Milestone payment, stock issued as consideration						$ 9,000
Common Stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)			18,720,930		20,239,839
Milestone payment, stock issued as consideration				$ 9,300
Underwritten Offering
Collaborative Agreements
Stock issued (in dollars per share)			$ 10.75			$ 10.75
Common Stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)	885,000	19,400,000
Outstanding warrants, convertible to common stock
Collaborative Agreements
Common stock issued from underwriting agreement (in shares)						101,787
Proceeds of exercise of warrants						$ 800
Outstanding warrants, convertible to common stock | Common Stock
Collaborative Agreements
Warrants exercise price (in dollars per share)			$ 7.98			$ 7.98

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