Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended	6 Months Ended
Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue:
Net product sales	$ 44,130	$ 21,309	$ 78,176	$ 38,005
Cost of goods sold	5,367	3,135	9,422	5,750
Gross profit	38,763	18,174	68,754	32,255
Operating expenses:
Research and development	70,981	34,660	135,574	75,458
Selling, general and administrative	42,578	29,172	86,881	56,568
Changes in fair value of contingent consideration payable	480	300	1,863	1,400
Depreciation and amortization	1,154	973	2,145	1,942
Total operating expenses	115,193	65,105	226,463	135,368
Loss from operations	(76,430)	(46,931)	(157,709)	(103,113)
Other income (expense):
Interest income	2,599	2,913	5,238	4,650
Interest expense	(4,625)	(4,560)	(11,079)	(9,048)
Loss on exchange of convertible notes	(4,501)	0	(40,624)	0
Change in fair value of derivatives	0	(7,600)	0	(2,739)
Other (expense) income	(877)	(5,316)	209	(2,554)
Loss before income tax	(83,834)	(61,494)	(203,965)	(112,804)
Income tax benefit	(717)	(339)	(885)	1,053
Net loss attributable to common stockholders	$ (84,551)	$ (61,833)	$ (204,850)	$ (111,751)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share)	$ (0.36)	$ (0.33)	$ (0.91)	$ (0.61)
Weighted-average common shares outstanding - basic and diluted (in shares)	238,089,824	188,621,423	225,848,013	182,303,128

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.