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Assets and Liabilities Measured at Fair Value - Components by Hierarchy Level (Details) $ in Thousands	3 Months Ended	6 Months Ended
	Mar. 31, 2019 USD ($)	Jun. 30, 2019 USD ($)	Dec. 31, 2018 USD ($)
Assets:
Fair value of assets		$ 358,901	$ 427,084
Liabilities:
Contingent consideration payable		21,247	19,700
Deferred compensation plan liability		3,874	2,732
Fair value of liabilities		25,121	22,432
Exchange agreement, aggregate principal amount		247,200
Milestone payment, stock issued as consideration		9,000
Common Stock
Liabilities:
Milestone payment, stock issued as consideration	$ 9,300
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Callidus Biopharma Inc
Liabilities:
Contingent consideration payable		$ 20,999
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability of Milestone Achievement | Minimum | Callidus Biopharma Inc
Liabilities:
Discount rate		0.75
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability of Milestone Achievement | Maximum | Callidus Biopharma Inc
Liabilities:
Discount rate		0.78
Commercial paper
Assets:
Fair value of assets		$ 112,026	115,141
Asset-backed securities
Assets:
Fair value of assets		73,093	68,135
Corporate debt securities
Assets:
Fair value of assets		169,558	240,726
Money market funds
Assets:
Fair value of assets		4,224	3,082
Level 2
Assets:
Fair value of assets		358,901	427,084
Liabilities:
Contingent consideration payable		0	0
Deferred compensation plan liability		3,874	2,732
Fair value of liabilities		3,874	2,732
Convertible debt, fair value		6,100
Level 2 | Commercial paper
Assets:
Fair value of assets		112,026	115,141
Level 2 | Asset-backed securities
Assets:
Fair value of assets		73,093	68,135
Level 2 | Corporate debt securities
Assets:
Fair value of assets		169,558	240,726
Level 2 | Money market funds
Assets:
Fair value of assets		4,224	3,082
Level 3
Liabilities:
Contingent consideration payable		21,247	19,700
Deferred compensation plan liability		0	0
Fair value of liabilities		$ 21,247	$ 19,700
Level 3 | ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability Weighted Discounted Cash Flow | Discount Rate | Callidus Biopharma Inc
Liabilities:
Discount rate		0.101

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