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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Outstanding warrants, convertible to common stock
Other Comprehensive Gain (Loss)
Accumulated Deficit
Increase (Decrease) in Stockholders' Equity            
Reclassification upon ASU 2018-02 adoption $ 0       $ (383) $ 383
Balance (in shares) at Dec. 31, 2017   166,989,790        
Balance at Dec. 31, 2017 352,850 $ 1,721 $ 1,400,758 $ 16,076 (2,095) (1,063,610)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   560,721        
Stock issued from exercise of stock options, net 3,978 $ 6 3,972      
Stock issued from equity financing (in shares)   20,239,839        
Stock issued from equity financing 294,584 $ 202 294,382      
Restricted stock tax vesting (in shares)   181,868        
Restricted stock tax vesting (1,912)   (1,912)      
Stock-based compensation 7,478   7,478      
Change in fair value of derivatives (83,199)   (83,199)      
Unrealized holding gain (loss) on available-for-sale securities (441)       (441)  
Foreign currency translation adjustment (1,805)       (1,805)  
Net loss (49,916)         (49,916)
Balance (in shares) at Mar. 31, 2018   187,972,218        
Balance at Mar. 31, 2018 521,617 $ 1,929 1,621,479 16,076 (4,724) (1,113,143)
Balance (in shares) at Dec. 31, 2017   166,989,790        
Balance at Dec. 31, 2017 352,850 $ 1,721 1,400,758 16,076 (2,095) (1,063,610)
Increase (Decrease) in Stockholders' Equity            
Unrealized holding gain (loss) on available-for-sale securities (19)          
Foreign currency translation adjustment 503          
Net loss (111,751)          
Balance (in shares) at Jun. 30, 2018   189,053,214        
Balance at Jun. 30, 2018 561,895 $ 1,939 1,723,865 13,063 (1,994) (1,174,978)
Balance (in shares) at Mar. 31, 2018   187,972,218        
Balance at Mar. 31, 2018 521,617 $ 1,929 1,621,479 16,076 (4,724) (1,113,143)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   542,056        
Stock issued from exercise of stock options, net 3,602 $ 5 3,597      
Restricted stock tax vesting (in shares)   85,726        
Restricted stock tax vesting (115)   (115)      
Stock-based compensation 6,341   6,341      
Warrants exercised (in shares)   453,214        
Warrants exercised 3,617 $ 5 6,625 (3,013)    
Change in fair value of derivatives 85,938   85,938      
Unrealized holding gain (loss) on available-for-sale securities 422       422  
Foreign currency translation adjustment 2,308       2,308  
Net loss (61,833)         (61,833)
Balance (in shares) at Jun. 30, 2018   189,053,214        
Balance at Jun. 30, 2018 $ 561,895 $ 1,939 1,723,865 13,063 (1,994) (1,174,978)
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924        
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 1,740,061 13,063 68 (1,412,222)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   578,451        
Stock issued from exercise of stock options, net 3,953 $ 6 3,947      
Restricted stock tax vesting (in shares)   301,058        
Restricted stock tax vesting (1,940)   (1,940)      
Stock issued for contingent consideration (in shares)   771,804        
Stock issued for contingent consideration 9,316 $ 8 9,308      
Stock-based compensation 12,744   12,744      
Warrants exercised (in shares)   101,787        
Warrants exercised 812 $ 1 1,487 (676)    
Equity component of the convertible notes (in shares)   39,043,690        
Equity component of the convertible notes 190,758 $ 390 190,368      
Termination of capped call confirmations 14,632   14,632      
Unrealized holding gain (loss) on available-for-sale securities 584       584  
Foreign currency translation adjustment (1,804)       (1,804)  
Net loss (120,299)         (120,299)
Balance (in shares) at Mar. 31, 2019   230,180,714        
Balance at Mar. 31, 2019 $ 451,668 $ 2,347 1,970,607 12,387 (1,152) (1,532,521)
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924        
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 1,740,061 13,063 68 (1,412,222)
Increase (Decrease) in Stockholders' Equity            
Unrealized holding gain (loss) on available-for-sale securities 562          
Foreign currency translation adjustment 77          
Net loss $ (204,850)          
Balance (in shares) at Jun. 30, 2019 254,513,522 254,513,522        
Balance at Jun. 30, 2019 $ 600,058 $ 2,589 2,201,447 12,387 707 (1,617,072)
Balance (in shares) at Mar. 31, 2019   230,180,714        
Balance at Mar. 31, 2019 451,668 $ 2,347 1,970,607 12,387 (1,152) (1,532,521)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   561,177        
Stock issued from exercise of stock options, net $ 2,807 $ 5 2,802      
Stock issued from equity financing (in shares) 18,700,000 18,720,930        
Stock issued from equity financing $ 188,994 $ 187 188,807      
Restricted stock tax vesting (in shares)   99,252        
Restricted stock tax vesting (615)   (615)      
Stock-based compensation 9,935   9,935      
Equity component of the convertible notes (in shares)   4,951,449        
Equity component of the convertible notes 24,718 $ 50 24,668      
Termination of capped call confirmations 5,243   5,243      
Unrealized holding gain (loss) on available-for-sale securities (22)       (22)  
Foreign currency translation adjustment 1,881       1,881  
Net loss $ (84,551)         (84,551)
Balance (in shares) at Jun. 30, 2019 254,513,522 254,513,522        
Balance at Jun. 30, 2019 $ 600,058 $ 2,589 $ 2,201,447 $ 12,387 $ 707 $ (1,617,072)