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v3.19.3

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Operating activities |  |
Net loss | $ (266,659) | $ (270,914)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Amortization of debt discount and deferred financing | 2,290 | 7,868
Depreciation and amortization | 3,261 | 3,015
Stock-based compensation | 31,522 | 20,873
Loss on exchange of convertible debt | 40,624 | 0
Change in fair value of derivatives | 0 | 2,739
Non-cash changes in the fair value of contingent consideration payable | 2,652 | 2,700
Foreign currency remeasurement loss | 2,665 | 775
Other | (136) | 0
Changes in operating assets and liabilities: |  |
Accounts receivable | (12,644) | (5,182)
Inventories | (2,016) | (2,049)
Prepaid expenses and other current assets | (3,321) | 2,633
Accounts payable and accrued expenses | 8,714 | 3,684
Other non-current assets and liabilities | 1,964 | (420)
Deferred reimbursements | (1,500) | (5,000)
Net cash used in operating activities | (192,584) | (239,278)
Investing activities |  |
Sale and redemption of marketable securities | 389,242 | 388,135
Purchases of marketable securities | (311,965) | (440,963)
Capital expenditures | (9,087) | (4,571)
Net cash provided by (used in) investing activities | 68,190 | (57,399)
Financing activities |  |
Proceeds from issuance of common stock, net of issuance costs | 188,994 | 294,584
Proceeds from senior secured term loan | 0 | 146,622
Payment of finance leases | (177) |
Payment of finance leases |  | (218)
Purchase of vested restricted stock units | (3,001) | (2,681)
Proceeds from termination of capped call confirmations | 19,875 | 0
Proceeds from exercise of stock options | 7,808 | 8,492
Proceeds of exercise of warrants | 812 | 3,617
Net cash provided by financing activities | 214,311 | 450,416
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (2,591) | (1,146)
Net increase in cash, cash equivalents, and restricted cash | 87,326 | 152,593
Cash, cash equivalents, and restricted cash at beginning of period | 82,375 | 51,237
Cash, cash equivalents, and restricted cash at end of period | 169,701 | 203,830
Cash paid during the period for interest |  |
Cash paid during the period for interest | 13,145 | 3,787
Capital expenditures, unpaid | 2,802 | 538
Payment of contingent consideration in shares | $ 9,316 | $ 0

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