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Consolidated Statements of Changes in Stockholders' Equity - USD ($) | Total | Common Stock | Additional Paid-In Capital | Warrants | Other Comprehensive Gain (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2017 |  | 166,989,790 |  |  |  |
Balance at Dec. 31, 2017 | $ 352,850,000 | $ 1,721,000 | $ 1,400,758,000 | $ 16,076,000 | $ (2,095,000) | $ (1,063,610,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 1,281,769 |  |  |  |
Stock issued from exercise of stock options, net | 8,491,000 | $ 13,000 | 8,478,000 |  |  |
Stock issued from equity financing (in shares) |  | 20,239,839 |  |  |  |
Stock issued from equity financing | 294,584,000 | $ 202,000 | 294,382,000 |  |  |
Restricted stock tax vesting (in shares) |  | 289,729 |  |  |  |
Restricted stock tax vesting | (2,681,000) |  | (2,681,000) |  |  |
Stock-based compensation | 20,873,000 |  | 20,873,000 |  |  |
Warrants exercised (in shares) |  | 453,214 |  |  |  |
Warrants exercised | 3,617,000 | $ 5,000 | 6,625,000 | (3,013,000) |  |
Change in fair value of derivatives | 2,739,000 |  | 2,739,000 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 225,000 |  |  |  | 225,000 |
Foreign currency translation adjustment | 1,167,000 |  |  |  | 1,167,000 |
Net loss | (270,914,000) |  |  |  |  | (270,914,000)
Balance (in shares) at Sep. 30, 2018 |  | 189,254,341 |  |  |  |
Balance at Sep. 30, 2018 | 410,951,000 | $ 1,941,000 | 1,731,174,000 | 13,063,000 | (1,086,000) | (1,334,141,000)
Balance (in shares) at Jun. 30, 2018 |  | 189,053,214 |  |  |  |
Balance at Jun. 30, 2018 | 561,895,000 | $ 1,939,000 | 1,723,865,000 | 13,063,000 | (1,994,000) | (1,174,978,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 178,992 |  |  |  |
Stock issued from exercise of stock options, net | 911,000 | $ 2,000 | 909,000 |  |  |
Restricted stock tax vesting (in shares) |  | 22,135 |  |  |  |
Restricted stock tax vesting | (654,000) |  | (654,000) |  |  |
Stock-based compensation | 7,054,000 |  | 7,054,000 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 244,000 |  |  |  | 244,000 |
Foreign currency translation adjustment | 665,000 |  |  |  | 665,000 |
Net loss | (159,163,000) |  |  |  |  | (159,163,000)
Balance (in shares) at Sep. 30, 2018 |  | 189,254,341 |  |  |  |
Balance at Sep. 30, 2018 | 410,951,000 | $ 1,941,000 | 1,731,174,000 | 13,063,000 | (1,086,000) | (1,334,141,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Reclassification upon ASU 2018-02 adoption | $ 0 |  |  |  | (383,000) | 383,000
Balance (in shares) at Dec. 31, 2018 | 189,383,924 | 189,383,924 |  |  |  |
Balance at Dec. 31, 2018 | $ 342,912,000 | $ 1,942,000 | 1,740,061,000 | 13,063,000 | 68,000 | (1,412,222,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 1,352,623 |  |  |  |
Stock issued from exercise of stock options, net | 7,808,000 | $ 13,000 | 7,795,000 |  |  |
Stock issued from equity financing (in shares) |  | 18,720,930 |  |  |  |
Stock issued from equity financing | 188,994,000 | $ 187,000 | 188,807,000 |  |  |
Restricted stock tax vesting (in shares) |  | 445,956 |  |  |  |
Restricted stock tax vesting | $ (3,001,000) |  | (3,001,000) |  |  |
Stock issued for contingent consideration (in shares) | 771,804 |  |  |  |  |
Stock issued for contingent consideration | $ 9,316,000 | $ 8,000 | 9,308,000 |  |  |
Stock-based compensation | $ 31,522,000 |  | 31,522,000 |  |  |
Warrants exercised (in shares) | 101,787 |  |  |  |  |
Warrants exercised | $ 812,000 | $ 1,000 | 1,487,000 | (676,000) |  |
Equity component of the convertible notes (in shares) |  | 43,995,139 |  |  |  |
Equity component of the convertible notes | 215,476,000 | $ 440,000 | 215,036,000 |  |  |
Termination of capped call confirmations | 19,875,000 |  | 19,875,000 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | 551,000 |  |  |  | 551,000 |
Foreign currency translation adjustment | 661,000 |  |  |  | 661,000 |
Net loss | $ (266,659,000) |  |  |  |  | (266,659,000)
Balance (in shares) at Sep. 30, 2019 | 254,772,163 | 254,772,163 |  |  |  |
Balance at Sep. 30, 2019 | $ 548,267,000 | $ 2,591,000 | 2,210,890,000 | 12,387,000 | 1,280,000 | (1,678,881,000)
Balance (in shares) at Jun. 30, 2019 |  | 254,513,522 |  |  |  |
Balance at Jun. 30, 2019 | 600,058,000 | $ 2,589,000 | 2,201,447,000 | 12,387,000 | 707,000 | (1,617,072,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Stock issued from exercise of stock options, net (in shares) |  | 212,995 |  |  |  |
Stock issued from exercise of stock options, net | 1,048,000 | $ 2,000 | 1,046,000 |  |  |
Restricted stock tax vesting (in shares) |  | 45,646 |  |  |  |
Restricted stock tax vesting | (446,000) |  | (446,000) |  |  |
Stock-based compensation | 8,843,000 |  | 8,843,000 |  |  |
Unrealized holding gain (loss) on available-for-sale securities | (11,000) |  |  |  | (11,000) |
Foreign currency translation adjustment | 584,000 |  |  |  | 584,000 |
Net loss | $ (61,809,000) |  |  |  |  | (61,809,000)
Balance (in shares) at Sep. 30, 2019 | 254,772,163 | 254,772,163 |  |  |  |
Balance at Sep. 30, 2019 | $ 548,267,000 | $ 2,591,000 | $ 2,210,890,000 | $ 12,387,000 | $ 1,280,000 | $ (1,678,881,000)

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