Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue:
Net product sales	$ 48,768	$ 20,596	$ 126,944	$ 58,601
Cost of goods sold	5,596	4,310	15,018	10,060
Gross profit	43,172	16,286	111,926	48,541
Operating expenses:
Research and development	58,892	138,227	194,466	213,685
Selling, general and administrative	39,680	31,867	126,561	88,435
Changes in fair value of contingent consideration payable	789	1,300	2,652	2,700
Depreciation and amortization	1,116	1,073	3,261	3,015
Total operating expenses	100,477	172,467	326,940	307,835
Loss from operations	(57,305)	(156,181)	(215,014)	(259,294)
Other income (expense):
Interest income	2,752	2,721	7,990	7,371
Interest expense	(4,026)	(4,715)	(15,105)	(13,763)
Loss on exchange of convertible notes	0	0	(40,624)	0
Change in fair value of derivatives	0	0	0	(2,739)
Other (expense) income	(3,481)	(1,039)	(3,272)	(3,593)
Loss before income tax	(62,060)	(159,214)	(266,025)	(272,018)
Income tax benefit	251	51	(634)	1,104
Net loss attributable to common stockholders	$ (61,809)	$ (159,163)	$ (266,659)	$ (270,914)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share)	$ (0.24)	$ (0.84)	$ (1.13)	$ (1.47)
Weighted-average common shares outstanding - basic and diluted (in shares)	254,674,422	189,162,841	235,527,540	184,606,790

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Name:	us-gaap_CostOfGoodsAndServicesSold
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.