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Assets and Liabilities Measured at Fair Value - Components by Hierarchy Level (Details) $ in Thousands	3 Months Ended	9 Months Ended
	Mar. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Dec. 31, 2018 USD ($)
Assets:
Fair value of assets		$ 351,802	$ 427,084
Liabilities:
Contingent consideration payable		22,036	19,700
Deferred compensation plan liability		4,003	2,732
Fair value of liabilities		26,039	22,432
Milestone payment, stock issued as consideration		9,000
Common Stock
Liabilities:
Milestone payment, stock issued as consideration	$ 9,300
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Callidus Biopharma Inc
Liabilities:
Contingent consideration payable		$ 21,766
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability of Milestone Achievement | Minimum | Callidus Biopharma Inc
Liabilities:
Discount rate		0.75
ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability of Milestone Achievement | Maximum | Callidus Biopharma Inc
Liabilities:
Discount rate		0.78
Commercial paper
Assets:
Fair value of assets		$ 114,808	115,141
Asset-backed securities
Assets:
Fair value of assets		75,255	68,135
Corporate debt securities
Assets:
Fair value of assets		139,745	240,726
U.S. government agency bonds
Assets:
Fair value of assets		17,666
Money market funds
Assets:
Fair value of assets		4,328	3,082
Level 2
Assets:
Fair value of assets		351,802	427,084
Liabilities:
Contingent consideration payable		0	0
Deferred compensation plan liability		4,003	2,732
Fair value of liabilities		4,003	2,732
Fair value of the Convertible Notes		4,200
Level 2 | Commercial paper
Assets:
Fair value of assets		114,808	115,141
Level 2 | Asset-backed securities
Assets:
Fair value of assets		75,255	68,135
Level 2 | Corporate debt securities
Assets:
Fair value of assets		139,745	240,726
Level 2 | U.S. government agency bonds
Assets:
Fair value of assets		17,666
Level 2 | Money market funds
Assets:
Fair value of assets		4,328	3,082
Level 3
Liabilities:
Contingent consideration payable		22,036	19,700
Deferred compensation plan liability		0	0
Fair value of liabilities		$ 22,036	$ 19,700
Level 3 | ATB200 Pompe Program | Contingent Consideration Liability Clinical and Regulatory Milestones | Probability Weighted Discounted Cash Flow | Discount Rate | Callidus Biopharma Inc
Liabilities:
Discount rate		0.098

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