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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance (in shares) at Dec. 31, 2017   166,989,790        
Balance at Dec. 31, 2017 $ 352,850,000 $ 1,721,000 $ 1,400,758,000 $ 16,076,000 $ (2,095,000) $ (1,063,610,000)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   1,281,769        
Stock issued from exercise of stock options, net 8,491,000 $ 13,000 8,478,000      
Stock issued from equity financing (in shares)   20,239,839        
Stock issued from equity financing 294,584,000 $ 202,000 294,382,000      
Restricted stock tax vesting (in shares)   289,729        
Restricted stock tax vesting (2,681,000)   (2,681,000)      
Stock-based compensation 20,873,000   20,873,000      
Warrants exercised (in shares)   453,214        
Warrants exercised 3,617,000 $ 5,000 6,625,000 (3,013,000)    
Change in fair value of derivatives 2,739,000   2,739,000      
Unrealized holding gain (loss) on available-for-sale securities 225,000       225,000  
Foreign currency translation adjustment 1,167,000       1,167,000  
Net loss (270,914,000)         (270,914,000)
Balance (in shares) at Sep. 30, 2018   189,254,341        
Balance at Sep. 30, 2018 410,951,000 $ 1,941,000 1,731,174,000 13,063,000 (1,086,000) (1,334,141,000)
Balance (in shares) at Jun. 30, 2018   189,053,214        
Balance at Jun. 30, 2018 561,895,000 $ 1,939,000 1,723,865,000 13,063,000 (1,994,000) (1,174,978,000)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   178,992        
Stock issued from exercise of stock options, net 911,000 $ 2,000 909,000      
Restricted stock tax vesting (in shares)   22,135        
Restricted stock tax vesting (654,000)   (654,000)      
Stock-based compensation 7,054,000   7,054,000      
Unrealized holding gain (loss) on available-for-sale securities 244,000       244,000  
Foreign currency translation adjustment 665,000       665,000  
Net loss (159,163,000)         (159,163,000)
Balance (in shares) at Sep. 30, 2018   189,254,341        
Balance at Sep. 30, 2018 410,951,000 $ 1,941,000 1,731,174,000 13,063,000 (1,086,000) (1,334,141,000)
Increase (Decrease) in Stockholders' Equity            
Reclassification upon ASU 2018-02 adoption $ 0       (383,000) 383,000
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924        
Balance at Dec. 31, 2018 $ 342,912,000 $ 1,942,000 1,740,061,000 13,063,000 68,000 (1,412,222,000)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   1,352,623        
Stock issued from exercise of stock options, net 7,808,000 $ 13,000 7,795,000      
Stock issued from equity financing (in shares)   18,720,930        
Stock issued from equity financing 188,994,000 $ 187,000 188,807,000      
Restricted stock tax vesting (in shares)   445,956        
Restricted stock tax vesting $ (3,001,000)   (3,001,000)      
Stock issued for contingent consideration (in shares) 771,804          
Stock issued for contingent consideration $ 9,316,000 $ 8,000 9,308,000      
Stock-based compensation $ 31,522,000   31,522,000      
Warrants exercised (in shares) 101,787          
Warrants exercised $ 812,000 $ 1,000 1,487,000 (676,000)    
Equity component of the convertible notes (in shares)   43,995,139        
Equity component of the convertible notes 215,476,000 $ 440,000 215,036,000      
Termination of capped call confirmations 19,875,000   19,875,000      
Unrealized holding gain (loss) on available-for-sale securities 551,000       551,000  
Foreign currency translation adjustment 661,000       661,000  
Net loss $ (266,659,000)         (266,659,000)
Balance (in shares) at Sep. 30, 2019 254,772,163 254,772,163        
Balance at Sep. 30, 2019 $ 548,267,000 $ 2,591,000 2,210,890,000 12,387,000 1,280,000 (1,678,881,000)
Balance (in shares) at Jun. 30, 2019   254,513,522        
Balance at Jun. 30, 2019 600,058,000 $ 2,589,000 2,201,447,000 12,387,000 707,000 (1,617,072,000)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   212,995        
Stock issued from exercise of stock options, net 1,048,000 $ 2,000 1,046,000      
Restricted stock tax vesting (in shares)   45,646        
Restricted stock tax vesting (446,000)   (446,000)      
Stock-based compensation 8,843,000   8,843,000      
Unrealized holding gain (loss) on available-for-sale securities (11,000)       (11,000)  
Foreign currency translation adjustment 584,000       584,000  
Net loss $ (61,809,000)         (61,809,000)
Balance (in shares) at Sep. 30, 2019 254,772,163 254,772,163        
Balance at Sep. 30, 2019 $ 548,267,000 $ 2,591,000 $ 2,210,890,000 $ 12,387,000 $ 1,280,000 $ (1,678,881,000)