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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Income Tax Disclosure [Abstract]

Schedule of Income (Loss) before Income Taxes

For financial reporting purposes, income (loss) before income taxes includes the following components:

		Years Ended December 31,
(in thousands)		2019				2018				2017
United States		$	(393,955	)		$	(309,183	)		$	(440,696	)
Foreign		38,045				(39,906		)		(8,425		)
Total		$	(355,910	)		$	(349,089	)		$	(449,121	)

Schedule of Income Tax Expense (Benefit)

Following were the components of income tax expense (benefit) for the years ended December 31, 2019, 2018, and 2017:

(in thousands)		2019				2018				2017
Current
Federal		$	—			$	—			$	—
State		—				6				9
Foreign		2,877				(100		)		2,276
Deferred
Federal		(984		)		—				(150,015		)
State		(1,415		)		—				(17,389		)
Foreign		—				—				—
Total		$	478			$	(94	)		$	(165,119	)

Schedule of Reconciliation of the Statutory Tax Rates and the Effective Tax Rates

A reconciliation of the statutory tax rates and the effective tax rates for the years ended December 31, 2019, 2018 and 2017 are as follows:

		Years Ended December 31,
		2019			2018			2017
Statutory rate		(21	)%		(21	)%		(34	)%
State taxes, net of federal benefit		—			(4	)		(5	)
Nondeductible IPR&D		—			6			(1	)
Contingent consideration		—			1			(18	)
Tax credits		(16	)		(10	)		(2	)
Foreign income tax rate differential		9			2			5
Impact of 2017 Act		—			—			27
Nondeductible debt conversion		(1	)		—			—
Other		—			—			5
Valuation allowance		29			26			(14	)
Net		—	%		—	%		(37	)%

Schedule of Significant Components of the Deferred Tax Assets and Liabilities

The significant components of the deferred tax assets and liabilities are as follows:

		For Years Ended December 31,
(in thousands)		2019				2018
Deferred tax assets
Intellectual property		$	46,521			$	48,339
Amortization/depreciation		2,329				3,732
Research tax credit		141,669				96,509
Net operating loss carry forwards		286,850				248,398
Deferred reimbursement		2,230				4,401
Non-cash stock issue		19,058				16,850
Interest carry forward limitation		2,224				1,032
Other		15,986				10,852
Gross deferred tax assets		516,867				430,113
Deferred tax liabilities
Business acquisition		(5,051		)		(6,465		)
Royalty payable		(46,521		)		(48,339		)
Convertible notes		(653		)		(16,666		)
Advanced R&D payments		(2,611		)		(2,103		)
Other		(725		)		—
Total net deferred tax assets		461,306				356,540
Less: valuation allowance		(466,357		)		(363,005		)
Net deferred tax liability		$	(5,051	)		$	(6,465	)

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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