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Description of Business (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
 1 Months Ended 3 Months Ended 12 Months Ended
Jul. 31, 2017
Jun. 30, 2019
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Jun. 30, 2018
Corporate Information, Status of Operations and Management Plans            
Stock issued from equity financing (in shares) 21.1 18.7        
Proceeds from issuance of common stock and warrants, net of issuance costs $ 243,000 $ 189,000 $ 188,994 $ 294,584 $ 243,037  
Exchange agreement, aggregate principal amount   $ 247,200 $ 247,200      
Exchange agreement, authorized (in shares)   44.0 44.0      
Common stock, par value (in dollars per share)   $ 0.01 $ 0.01 $ 0.01   $ 0.01
Accumulated deficit     $ (1,768,610) $ (1,412,222)    
Underwritten Offering            
Corporate Information, Status of Operations and Management Plans            
Stock issued (in dollars per share)   $ 10.75