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Income Taxes - Deferred and Valuation (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Deferred tax assets    
Intellectual property $ 46,521 $ 48,339
Amortization/depreciation 2,329 3,732
Research tax credit 141,669 96,509
Net operating loss carry forwards 286,850 248,398
Deferred reimbursement 2,230 4,401
Non-cash stock issue 19,058 16,850
Interest carry forward limitation 2,224 1,032
Other 15,986 10,852
Gross deferred tax assets 516,867 430,113
Deferred tax liabilities    
Business acquisition (5,051) (6,465)
Royalty payable (46,521) (48,339)
Convertible notes (653) (16,666)
Advanced R&D payments (2,611) (2,103)
Other (725) 0
Total net deferred tax assets 461,306 356,540
Less: valuation allowance (466,357) (363,005)
Net deferred tax liability (5,051) $ (6,465)
Increase in the valuation allowance $ 103,400