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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Income Statement [Abstract]      
Net product sales $ 182,237 $ 91,245 $ 36,930
Cost of goods sold 21,963 14,404 6,236
Gross profit 160,274 76,841 30,694
Operating expenses:      
Research and development 286,378 270,902 149,310
Selling, general, and administrative 169,861 127,200 88,671
Changes in fair value of contingent consideration payable 3,297 3,300 (234,322)
Loss on impairment of assets 0 0 465,427
Depreciation and amortization 4,775 4,216 3,593
Total operating expenses 464,311 405,618 472,679
Loss from operations (304,037) (328,777) (441,985)
Other income (expenses):      
Interest income 10,249 10,461 4,096
Interest expense (18,872) (22,402) (17,240)
Loss on exchange of convertible notes (40,624) 0 0
Change in fair value of derivatives 0 (2,739) 0
Other (expense) income (2,626) (5,632) 6,008
Loss before income tax (355,910) (349,089) (449,121)
Income tax (expense) benefit (478) 94 165,119
Net loss attributable to common stockholders $ (356,388) $ (348,995) $ (284,002)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (1.48) $ (1.88) $ (1.85)
Weighted-average common shares outstanding - basic and diluted (in shares) 240,421,001 185,790,021 153,355,144