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Acquisitions (Details) $ in Thousands	1 Months Ended			3 Months Ended			12 Months Ended
	Sep. 30, 2018 USD ($) program	Apr. 30, 2017 USD ($)	Jul. 31, 2016 USD ($) shares	Mar. 31, 2019 USD ($)	Sep. 30, 2017 USD ($)	Mar. 31, 2017	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)
Acquisitions
Number of gene therapy programs for neurologic LSDs developed | program	10
Milestone payment				$ 9,000
Loss on impairment of assets							$ 0	$ 0	$ 465,427
Changes in fair value of contingent consideration payable							3,297	3,300	(234,322)
Contingent consideration payable							22,681	19,700
Milestone Payment | Callidus
Acquisitions
Milestone payment				$ 9,000
Fixed assets
Acquisitions
Loss on impairment of assets									1,700
MiaMed Inc
Acquisitions
Asset acquisition, total consideration, stock and cash			$ 6,500
Asset acquisition, cash consideration paid			1,800
Asset acquisition, potential aggregate deal value			$ 89,500
Charges to research expense for stock issued in asset acquisition										$ 6,500
MiaMed Inc | Amicus | Common Stock
Acquisitions
Consideration paid in common stock (in shares) | shares			825,603
Scioderm
Acquisitions
Enrollment rate						100.00%
Milestone payment		$ 10,000
Loss on impairment of assets									$ 463,700
Changes in fair value of contingent consideration payable					$ 254,700
Selling , general and administrative costs due to wind-down					400
Research and development expenses due to wind-down					8,100
Income tax benefit due to wind-down					$ 164,700
Callidus
Acquisitions
Contingent consideration payable							22,700
Callidus | Changes in fair value of contingent consideration payable
Acquisitions
Changes in fair value of contingent consideration payable							$ 3,300
Clinical, Regulatory and Commercial milestones | MiaMed Inc | Maximum
Acquisitions
Contingent consideration payable upon achievement of milestones			$ 83,000
Celenex
Acquisitions
Research and development expense	$ 100,000							$ 100,000
Contingent consideration based on the achievement of certain milestones	15,000
Contingent consideration based on the achievement of regulatory milestones	262,000
Maximum payment under contingent consideration	75,000
Celenex | Nationwide Children's Hospital
Acquisitions
Contingent consideration based on the achievement of certain milestones	$ 7,800

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