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Stockholders' Equity - Common Stock and Warrants (Details) $ / shares in Units, $ in Thousands			1 Months Ended				3 Months Ended		12 Months Ended
	Feb. 16, 2018 shares	Feb. 15, 2018 shares	Mar. 31, 2019 USD ($) $ / shares shares	Apr. 30, 2018 USD ($) $ / shares shares	Feb. 28, 2018 USD ($) $ / shares shares	Jul. 31, 2017 USD ($) $ / shares shares	Jun. 30, 2019 USD ($) $ / shares shares	Mar. 31, 2019 USD ($) $ / shares	Dec. 31, 2019 USD ($) vote $ / shares shares	Dec. 31, 2018 USD ($) $ / shares shares	Dec. 31, 2017 USD ($) shares	Jun. 30, 2018 $ / shares shares	Jun. 07, 2018 shares
Convertible Debt
Common stock, shares authorized (in shares) | shares									500,000,000	500,000,000	250,000,000	500,000,000	500,000,000
Voting right for each share held, number | vote									1
Stock issued from equity financing (in shares) | shares						21,100,000	18,700,000
Gross cash proceeds from warrant exercises									$ 812	$ 3,617	$ 0
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions						$ 243,000	$ 189,000		$ 188,994	$ 294,584	$ 243,037
Contingent consideration, milestone payment								$ 9,000
Milestone payment, stock issued as consideration								$ 9,000
Common stock, par value (in dollars per share) | $ / shares							$ 0.01		$ 0.01	$ 0.01		$ 0.01
Exchange agreement, aggregate principal amount							$ 247,200		$ 247,200
Exchange agreement, authorized (in shares) | shares							44,000,000.0		44,000,000.0
Price per share of common stock issued (in dollars per share) | $ / shares						$ 12.25
Warrants
Convertible Debt
Stock issued from equity financing (in shares) | shares			101,787	453,214
Gross cash proceeds from warrant exercises			$ 800	$ 3,600
Underwritten Offering
Convertible Debt
Stock issued (in dollars per share) | $ / shares							$ 10.75
Common Stock
Convertible Debt
Stock issued from equity financing (in shares) | shares	885,000	19,400,000			20,200,000
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions					$ 294,600
Price per share of common stock issued (in dollars per share) | $ / shares					$ 15.50
Common Stock | Warrants
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares			$ 7.98	$ 7.98				$ 7.98
Common Stock
Convertible Debt
Stock issued from equity financing (in shares) | shares									18,720,930	20,239,839	21,122,449
Milestone payment, stock issued as consideration								$ 9,300

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