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- Assets and Liabilities (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2019 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)
Assets:
Fair value of assets		$ 314,270	$ 427,084
Liabilities:
Contingent consideration payable		22,681	19,700
Deferred compensation plan liability		4,419	2,732
Fair value of liabilities		27,100	22,432
Milestone payment, stock issued as consideration	$ 9,000
Callidus
Liabilities:
Contingent consideration payable		22,700
ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Callidus
Liabilities:
Contingent consideration payable		$ 22,390
ATB-200 Pompe Program | Minimum | Clinical and Regulatory Approval Milestones | Callidus | Probability of Milestone Achievement
Liabilities:
Contingent consideration, measurement input		0.750
ATB-200 Pompe Program | Maximum | Clinical and Regulatory Approval Milestones | Callidus | Probability of Milestone Achievement
Liabilities:
Contingent consideration, measurement input		0.780
Convertible Notes | 2016 Convertible Notes
Liabilities:
Fair value of the debt		$ 5,000
Commercial paper
Assets:
Fair value of assets		73,710	115,141
Asset-backed securities
Assets:
Fair value of assets		77,810	68,135
Corporate debt securities
Assets:
Fair value of assets		145,991	240,726
U.S. government agency bonds
Assets:
Fair value of assets		11,991
Money market
Assets:
Fair value of assets		4,768	3,082
Level 2
Assets:
Fair value of assets		314,270	427,084
Liabilities:
Contingent consideration payable		0	0
Deferred compensation plan liability		4,419	2,732
Fair value of liabilities		4,419	2,732
Level 2 | Commercial paper
Assets:
Fair value of assets		73,710	115,141
Level 2 | Asset-backed securities
Assets:
Fair value of assets		77,810	68,135
Level 2 | Corporate debt securities
Assets:
Fair value of assets		145,991	240,726
Level 2 | U.S. government agency bonds
Assets:
Fair value of assets		11,991
Level 2 | Money market
Assets:
Fair value of assets		4,768	3,082
Level 3
Liabilities:
Contingent consideration payable		22,681	19,700
Deferred compensation plan liability		0	0
Fair value of liabilities		$ 22,681	$ 19,700
Level 3 | ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Probability Weighted Discounted Cash Flow | Callidus | Discount Rate
Liabilities:
Contingent consideration, measurement input		0.096
Common Stock
Liabilities:
Milestone payment, stock issued as consideration	$ 9,300

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