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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Balance (in shares) at Dec. 31, 2016   142,691,986        
Balance at Dec. 31, 2016 $ 360,151 $ 1,480 $ 1,120,156 $ 16,076 $ 2,047 $ (779,608)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   2,878,681        
Stock issued from exercise of stock options, net 16,301 $ 29 16,272      
Stock issued from equity financing (in shares)   21,122,449        
Stock issued from equity financing 243,037 $ 212 242,825      
Restricted stock tax vesting (in shares)   296,674        
Restricted stock tax vesting (1,596)   (1,596)      
Stock-based compensation 23,101   23,101      
Unrealized holding loss on available-for-sale securities (538)       (538)  
Foreign currency translation adjustment (3,604)       (3,604)  
Net loss (284,002)         (284,002)
Balance (in shares) at Dec. 31, 2017   166,989,790        
Balance at Dec. 31, 2017 352,850 $ 1,721 1,400,758 16,076 (2,095) (1,063,610)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   1,397,908        
Stock issued from exercise of stock options, net 9,144 $ 14 9,130      
Stock issued from equity financing (in shares)   20,239,839        
Stock issued from equity financing 294,583 $ 202 294,381      
Restricted stock tax vesting (in shares)   303,173        
Restricted stock tax vesting (2,832)   (2,832)      
Stock-based compensation 29,260   29,260      
Reclassification upon ASU 2018-02 adoption         (383) 383
Warrants exercised (in shares)   453,214        
Warrants exercised 3,617 $ 5 6,625 (3,013)    
Change in fair value of derivatives 2,739   2,739      
Unrealized holding loss on available-for-sale securities 9       9  
Foreign currency translation adjustment 2,537       2,537  
Net loss $ (348,995)         (348,995)
Balance (in shares) at Dec. 31, 2018 189,383,924 189,383,924        
Balance at Dec. 31, 2018 $ 342,912 $ 1,942 1,740,061 13,063 68 (1,412,222)
Increase (Decrease) in Stockholders' Equity            
Stock issued from exercise of stock options, net (in shares)   1,967,087        
Stock issued from exercise of stock options, net 11,476 $ 20 11,456      
Stock issued from equity financing (in shares)   18,720,930        
Stock issued from equity financing 188,994 $ 187 188,807      
Restricted stock tax vesting (in shares)   477,198        
Restricted stock tax vesting (3,235)   (3,235)      
Stock issued for contingent consideration (in shares)   771,804        
Stock issued for contingent consideration 9,316 $ 8 9,308      
Stock-based compensation 44,430          
Warrants exercised (in shares)   101,787        
Warrants exercised 812 $ 1 1,487 (676)    
Equity component of the convertible notes (in shares)   43,995,139        
Equity component of the convertible notes 215,476 $ 440 215,036      
Termination of capped call confirmations 19,875   19,875      
Unrealized holding loss on available-for-sale securities 467       467  
Foreign currency translation adjustment 2,290       2,290  
Net loss $ (356,388)         (356,388)
Balance (in shares) at Dec. 31, 2019 255,417,869 255,417,869        
Balance at Dec. 31, 2019 $ 476,425 $ 2,598 $ 2,227,225 $ 12,387 $ 2,825 $ (1,768,610)