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Collaborative Agreements (Details)	1 Months Ended		3 Months Ended								12 Months Ended
	Oct. 31, 2018 USD ($)	Nov. 30, 2013 USD ($)	Dec. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)
Collaborative Agreements
Revenue recognized			$ 55,293,000	$ 48,768,000	$ 44,130,000	$ 34,046,000	$ 32,644,000	$ 20,596,000	$ 21,309,000	$ 16,696,000	$ 182,237,000	$ 91,245,000	$ 36,930,000
Deferred reimbursements			8,906,000				10,156,000				8,906,000	10,156,000
Accounts payable, accrued expenses, and other current liabilities			120,373,000				$ 80,625,000				120,373,000	$ 80,625,000
Collaborative Arrangements
Collaborative Agreements
Conditional aggregate payments per indication	$ 86,500,000
Collaboration Agreement, Discovery Program Fee			10,000,000.0								10,000,000.0
Payments for collaborative agreement	$ 7,000,000
Collaborative Arrangements | GSK
Collaborative Agreements
Payments for collaborative agreement											1,500,000
Accrued payments for collaborative arrangement			4,000,000.0								4,000,000.0
Revised Agreement | GSK
Collaborative Agreements
Upfront payment received		$ 0
Potential milestone payments upon achievement of post-approval and sales-based milestones		$ 40,000,000
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones		8
Revenue recognized											15,500,000
Deferred reimbursements			10,200,000								10,200,000
Accounts payable, accrued expenses, and other current liabilities			$ 5,200,000								$ 5,200,000

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Represents the amount of potential payments upon achievement of post-approval and sales-based milestones.

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Represents information pertaining to the number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones.

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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