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v3.20.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2020 | Sep. 30, 2019
Operating activities |  |
Net loss | $ (205,451) | $ (266,659)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Amortization of debt discount and deferred financing | 1,124 | 2,290
Depreciation and amortization | 6,299 | 3,261
Stock-based compensation | 36,912 | 31,522
Loss on exchange of convertible debt | 0 | 40,624
Loss on extinguishment of debt | 7,276 | 0
Non-cash changes in the fair value of contingent consideration payable | 2,680 | 2,652
Foreign currency remeasurement loss | (1,084) | 2,665
Other | 0 | (136)
Changes in operating assets and liabilities: |  |
Accounts receivable | (10,845) | (12,644)
Inventories | 2,182 | (2,016)
Prepaid expenses and other current assets | 4,377 | (3,321)
Accounts payable and accrued expenses | (23,424) | 8,714
Other non-current assets and liabilities | (2,264) | 1,964
Deferred reimbursements | (1,250) | (1,500)
Net cash used in operating activities | (183,468) | (192,584)
Investing activities |  |
Sale and redemption of marketable securities | 272,679 | 389,242
Purchases of marketable securities | (261,322) | (311,965)
Capital expenditures | (2,160) | (9,087)
Net cash provided by investing activities | 9,197 | 68,190
Financing activities |  |
Proceeds from issuance of common stock, net of issuance costs | 0 | 188,994
Payment of long-term debt | (155,249) | 0
Proceeds from long-term debt, net of issuance costs | 385,929 | 0
Payment of finance leases | (58) | (177)
Purchase of vested restricted stock units | (9,340) | (3,001)
Proceeds from termination of capped call confirmations | 0 | 19,875
Proceeds from exercise of stock options | 20,028 | 7,808
Proceeds of exercise of warrants | 0 | 812
Net cash provided by financing activities | 241,310 | 214,311
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 45 | (2,591)
Net increase in cash, cash equivalents, and restricted cash at the end of the period | 67,084 | 87,326
Cash, cash equivalents, and restricted cash at beginning of period | 146,341 | 82,375
Cash, cash equivalents, and restricted cash at the end of period | 213,425 | 169,701
Supplemental disclosures of cash flow information |  |
Tenant improvements paid through lease incentives | 470 | 14,875
Cash paid during the period for interest | 16,712 | 13,145
Contingent consideration paid in shares | 0 | 9,316
Capital expenditures unpaid at the end of period | $ 265 | $ 2,802

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