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Share-Based Compensation - Expense Summary (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 15,908 $ 8,843 $ 36,912 $ 31,522
Research and development expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense 8,626 3,106 17,241 12,090
Selling, general, and administrative expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 7,282 $ 5,737 $ 19,671 $ 19,432