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Acquisitions (Details) $ in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2018 USD ($) program | Dec. 31, 2018 USD ($)
Acquisitions |  |
Number of gene therapy programs for neurologic LSDs developed | program | 10 |
Celenex |  |
Acquisitions |  |
Contingent consideration based on the achievement of certain milestones | $ 10.0 |
Contingent consideration based on the achievement of regulatory milestones | 220.0 |
Maximum payment under contingent consideration | 75.0 |
Research and development expense |  | $ 100.0
Celenex | Nationwide Children's Hospital |  |
Acquisitions |  |
Contingent consideration based on the achievement of certain milestones | $ 7.8 |

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