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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2020
Income Tax Disclosure [Abstract] |
Schedule of loss before Income Taxes | For financial reporting purposes, loss before income taxes includes the following components:
|  | Years Ended December 31,
(in thousands) |  | 2020 |  | 2019 |  | 2018
United States |  | $ | (365,332) |  |  | $ | (393,955) |  |  | $ | (309,183) |
Foreign |  | 91,078 |  |  | 38,045 |  |  | (39,906) |
Total |  | $ | (274,254) |  |  | $ | (355,910) |  |  | $ | (349,089) |
Schedule of Income Tax Expense (Benefit) | Following were the components of income tax expense (benefit) for the years ended December 31, 2020, 2019, and 2018:
(in thousands) |  | 2020 |  | 2019 |  | 2018
Current |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
State |  | — |  |  | — |  |  | 6 |
Foreign |  | 4,163 |  |  | 2,877 |  |  | (100) |
Deferred |  |  |  |  |  |
Federal |  | (1,410) |  |  | (984) |  |  | — |
State |  | (155) |  |  | (1,415) |  |  | — |
Foreign |  | — |  |  | — |  |  | — |
Total |  | $ | 2,598 |  |  | $ | 478 |  |  | $ | (94) |
Schedule of Reconciliation of the Statutory Tax Rates and the Effective Tax Rates | A reconciliation of the statutory tax rates and the effective tax rates for the years ended December 31, 2020, 2019, and 2018 are as follows:
|  | Years Ended December 31,
|  | 2020 |  | 2019 |  | 2018
Statutory rate |  | (21) | % |  | (21) | % |  | (21) | %
State taxes, net of federal benefit |  | — |  |  | — |  |  | (4) |
Nondeductible IPR&D |  | — |  |  | — |  |  | 6 |
Contingent consideration |  | — |  |  | — |  |  | 1 |
Tax credits |  | (7) |  |  | (16) |  |  | (10) |
Impact of foreign operations |  | 4 |  |  | 9 |  |  | 2 |
Nondeductible executive compensation |  | 2 |  |  | 1 |  |  | — |
Nondeductible debt conversion |  | — |  |  | (1) |  |  | — |
Other |  | — |  |  | (1) |  |  | — |
Valuation allowance |  | 23 |  |  | 29 |  |  | 26 |
Net |  | 1 | % |  | — | % |  | — | %
Schedule of Significant Components of the Deferred Tax Assets and Liabilities | The significant components of the deferred tax assets and liabilities are as follows:
|  | Years Ended December 31,
(in thousands) |  | 2020 |  | 2019
Deferred tax assets |  |  |  |
Intellectual property |  | $ | 68,209 |  |  | $ | 46,521 |
Amortization/depreciation |  | 489 |  |  | 2,329 |
Research tax credit |  | 182,651 |  |  | 141,669 |
Net operating loss carry forwards |  | 305,876 |  |  | 286,850 |
Deferred reimbursements |  | 1,912 |  |  | 2,230 |
Non-cash stock issue |  | 17,553 |  |  | 19,058 |
Interest carry forward limitation |  | 5,655 |  |  | 2,224 |
Lease liability |  | 9,235 |  |  | 6,983 |
Other |  | 10,855 |  |  | 13,921 |
Gross deferred tax assets |  | 602,435 |  |  | 521,785 |
Deferred tax liabilities |  |  |  |
Business acquisition |  | (4,937) |  |  | (5,051) |
Royalty payable |  | (68,209) |  |  | (46,521) |
Convertible notes |  | (94) |  |  | (653) |
Advanced R&D payments |  | (1,776) |  |  | (2,611) |
Right of use asset |  | (3,420) |  |  | (5,643) |
Total net deferred tax assets |  | 523,999 |  |  | 461,306 |
Less: valuation allowance |  | (528,895) |  |  | (466,357) |
Net deferred tax liability |  | $ | (4,896) |  |  | $ | (5,051) |

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