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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating activities |  |  |
Net loss | $ (276,852) | $ (356,388) | $ (348,995)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Amortization of debt discount and deferred financing | 1,794 | 2,546 | 10,976
Depreciation and amortization | 8,846 | 4,775 | 4,216
Stock-based compensation | 49,151 | 44,430 | 29,260
Loss on exchange of convertible notes | 0 | 40,624 | 0
Loss on extinguishment of debt | 7,276 | 0 | 0
Change in fair value of derivatives | 0 | 0 | 2,739
Non-cash changes in the fair value of contingent consideration payable | 3,144 | 3,297 | 3,300
Foreign currency remeasurement loss | 5,471 | 254 | 3,217
Non-cash deferred taxes | (155) | (1,415) | 0
Other | 99 | (149) | 59
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (11,219) | (11,114) | (13,294)
Inventories | (4,639) | (5,114) | (4,205)
Prepaid expenses and other current assets | (8,766) | (3,287) | 2,488
Accounts payable, accrued expenses, and other current liabilities | (10,610) | 46,742 | 17,115
Other non-current assets and liabilities | 4,420 | (10,117) | (581)
Deferred reimbursements | (1,250) | (5,500) | (6,250)
Net cash used in operating activities | (233,290) | (250,416) | (299,955)
Investing activities |  |  |
Sale and redemption of marketable securities | 354,826 | 499,047 | 463,502
Purchases of marketable securities | (365,178) | (383,882) | (578,394)
Capital expenditures | (3,227) | (20,012) | (6,308)
Net cash (used in) provided by investing activities | (13,579) | 95,153 | (121,200)
Financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 0 | 188,994 | 294,584
Payment of long-term debt | (155,249) | 0 | 0
Proceeds from long-term debt, net of issuance costs | 385,929 | 0 | 146,596
Payment of finance leases | (76) | (420) | (334)
Purchase of vested restricted stock units | (10,028) | (3,235) | (2,832)
Proceeds from termination of capped call confirmations | 0 | 19,875 | 0
Proceeds from exercise of stock options | 42,282 | 11,476 | 9,144
Proceeds from exercise of warrants | 0 | 812 | 3,617
Net cash provided by financing activities | 262,858 | 217,502 | 450,775
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 3,830 | 1,729 | 1,518
Net increase in cash, cash equivalents, and restricted cash | 19,819 | 63,968 | 31,138
Cash, cash equivalents, and restricted cash at the beginning of the year | 146,343 | 82,375 | 51,237
Cash, cash equivalents, and restricted cash at the end of the year | 166,162 | 146,343 | 82,375
Supplemental disclosures of cash flow information |  |  |
Tenant improvements paid through lease incentive | 470 | 19,388 | 0
Cash paid during the period for interest | 24,683 | 16,966 | 7,500
Contingent consideration paid in shares | 0 | 9,316 | 0
Capital expenditures unpaid at the end of period | 985 | 1,865 | 106
Cash paid for taxes | $ 10,371 | $ 691 | $ 1,062

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