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Collaborative Agreements (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Oct. 31, 2018 USD ($) | Nov. 30, 2013 USD ($) market | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
Collaborative Agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  | $ 70,571 | $ 67,437 | $ 62,353 | $ 60,525 | $ 55,293 | $ 48,768 | $ 44,130 | $ 34,046 | $ 260,886 | $ 182,237 | $ 91,245
Deferred reimbursements |  |  | 7,406 |  |  |  | 8,906 |  |  |  | 7,406 | 8,906 |
Accrued expenses and other current liabilities |  |  | 96,841 |  |  |  | $ 99,901 |  |  |  | 96,841 | $ 99,901 |
Collaborative Arrangements |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Conditional aggregate payments per indication | $ 88,000 |  |  |  |  |  |  |  |  |  |  |  |
Discovery program fee | $ 10,000 |  |  |  |  |  |  |  |  |  |  |  |
Term of agreement | 5 years |  |  |  |  |  |  |  |  |  |  |  |
Payments for collaborative agreement | $ 7,000 |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements | GSK |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for collaborative agreement |  |  |  |  |  |  |  |  |  |  | 1,300 |  |
Revised Agreement | GSK |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments upon achievement of post-approval and sales-based milestones |  | $ 40,000 |  |  |  |  |  |  |  |  |  |  |
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market |  | 8 |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  |  |  | 21,700 |  |
Deferred reimbursements |  |  | 8,900 |  |  |  |  |  |  |  | 8,900 |  |
Accrued expenses and other current liabilities |  |  | $ 6,600 |  |  |  |  |  |  |  | $ 6,600 |  |

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