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Stockholders' Equity - Common Stock and Warrants (Details) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Feb. 28, 2021 USD ($) $ / shares shares | Mar. 31, 2019 USD ($) $ / shares shares | Apr. 30, 2018 USD ($) $ / shares shares | Feb. 28, 2018 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) $ / shares shares | Mar. 31, 2019 USD ($) $ / shares | Dec. 31, 2020 USD ($) vote $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares | Dec. 31, 2018 USD ($) shares | Jun. 30, 2018 $ / shares shares | May 31, 2018 shares
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized (in shares) | shares |  |  |  |  |  |  | 500,000,000 | 500,000,000 |  | 500,000,000 | 250,000,000
Voting right for each share held, number | vote |  |  |  |  |  |  | 1 |  |  |  |
Stock issued from equity financing (in shares) | shares |  |  |  |  | 18,700,000 |  |  |  |  |  |
Gross cash proceeds from warrant exercises |  |  |  |  |  |  | $ 0 | $ 812 | $ 3,617 |  |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  |  |  | $ 189,000 |  | $ 0 | $ 188,994 | $ 294,584 |  |
Contingent consideration, milestone payment |  |  |  |  |  | $ 9,000 |  |  |  |  |
Milestone payment, stock issued as consideration |  |  |  |  |  | 9,000 |  |  |  |  |
Exchange agreement, aggregate principal amount |  |  |  |  | $ 247,200 |  |  |  |  |  |
Exchange agreement, authorized (in shares) | shares |  |  |  |  | 44,000,000.0 |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  | $ 0.01 |  | $ 0.01 | $ 0.01 |  | $ 0.01 |
Common Stock |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  |  |  |  |  |  |  | 18,720,930 | 20,239,839 |  |
Milestone payment, stock issued as consideration |  |  |  |  |  | $ 9,300 |  |  |  |  |
Underwritten Offering |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Stock issued (in dollars per share) | $ / shares |  |  |  |  | $ 10.75 |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  |  |  | 20,200,000 |  |  |  |  |  |  |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  |  | $ 294,600 |  |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) | $ / shares |  |  |  | $ 15.50 |  |  |  |  |  |  |
Warrants |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  | 101,787 | 453,214 |  |  |  |  |  |  |  |
Gross cash proceeds from warrant exercises |  | $ 800 | $ 3,600 |  |  |  |  |  |  |  |
Warrants | Common Stock |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares |  | $ 7.98 | $ 7.98 |  |  | $ 7.98 |  |  |  |  |
Warrants | Subsequent Event |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares | 1,050,000 |  |  |  |  |  |  |  |  |  |
Gross cash proceeds from warrant exercises | $ 7,400 |  |  |  |  |  |  |  |  |  |
Warrants | Subsequent Event | Common Stock |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares | $ 7.06 |  |  |  |  |  |  |  |  |  |

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