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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Statement [Abstract]      
Net product sales $ 260,886 $ 182,237 $ 91,245
Cost of goods sold 31,044 21,963 14,404
Gross profit 229,842 160,274 76,841
Operating expenses:      
Research and development 308,443 286,378 270,902
Selling, general, and administrative 156,407 169,861 127,200
Changes in fair value of contingent consideration payable 3,144 3,297 3,300
Depreciation and amortization 8,846 4,775 4,216
Total operating expenses 476,840 464,311 405,618
Loss from operations (246,998) (304,037) (328,777)
Other (expense) income:      
Interest income 3,226 10,249 10,461
Interest expense (22,425) (18,872) (22,402)
Loss on exchange of convertible notes 0 (40,624) 0
Loss on extinguishment of debt (7,276) 0 0
Change in fair value of derivatives 0 0 (2,739)
Other expense (781) (2,626) (5,632)
Loss before income tax (274,254) (355,910) (349,089)
Income tax (expense) benefit (2,598) (478) 94
Net loss attributable to common stockholders $ (276,852) $ (356,388) $ (348,995)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (1.07) $ (1.48) $ (1.88)
Weighted-average common shares outstanding - basic and diluted (in shares) 258,867,380 240,421,001 185,790,021