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Summary of Significant Accounting Policies - Revenue by Geographical Area (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Disaggregation of Revenue [Line Items]                      
Net product sales $ 70,571 $ 67,437 $ 62,353 $ 60,525 $ 55,293 $ 48,768 $ 44,130 $ 34,046 $ 260,886 $ 182,237 $ 91,245
U.S.                      
Disaggregation of Revenue [Line Items]                      
Net product sales                 80,046 52,478 7,223
Ex-U.S.                      
Disaggregation of Revenue [Line Items]                      
Net product sales                 $ 180,840 $ 129,759 $ 84,022