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Assets and Liabilities Measured at Fair Value (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2019 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Assets:
Fair value of assets		$ 324,055	$ 314,270
Liabilities:
Contingent consideration payable		25,825	22,681
Deferred compensation plan liability		4,078	4,419
Fair value of liabilities		29,903	27,100
Milestone payment, stock issued as consideration	$ 9,000
Common Stock
Liabilities:
Milestone payment, stock issued as consideration	$ 9,300
ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Callidus
Liabilities:
Contingent consideration payable		$ 25,101
ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Callidus | Probability of Milestone Achievement | Minimum
Liabilities:
Contingent consideration, measurement input		0.75
ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Callidus | Probability of Milestone Achievement | Maximum
Liabilities:
Contingent consideration, measurement input		0.78
Convertible Notes | 2016 Convertible Notes
Liabilities:
Fair value of the debt		$ 10,900
Commercial paper
Assets:
Fair value of assets		217,095	73,710
Asset-backed securities
Assets:
Fair value of assets		9,438	77,810
Corporate debt securities
Assets:
Fair value of assets		39,513	145,991
U.S. government agency bonds
Assets:
Fair value of assets		53,582	11,991
Money market
Assets:
Fair value of assets		4,427	4,768
Level 2
Assets:
Fair value of assets		324,055	314,270
Liabilities:
Contingent consideration payable		0	0
Deferred compensation plan liability		4,078	4,419
Fair value of liabilities		4,078	4,419
Level 2 | Commercial paper
Assets:
Fair value of assets		217,095	73,710
Level 2 | Asset-backed securities
Assets:
Fair value of assets		9,438	77,810
Level 2 | Corporate debt securities
Assets:
Fair value of assets		39,513	145,991
Level 2 | U.S. government agency bonds
Assets:
Fair value of assets		53,582	11,991
Level 2 | Money market
Assets:
Fair value of assets		4,427	4,768
Level 3
Liabilities:
Contingent consideration payable		25,825	22,681
Deferred compensation plan liability		0	0
Fair value of liabilities		$ 25,825	$ 22,681
Level 3 | ATB-200 Pompe Program | Clinical and Regulatory Approval Milestones | Probability Weighted Discounted Cash Flow | Callidus | Discount Rate
Liabilities:
Contingent consideration, measurement input		0.075

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