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Income Taxes - Statutory Rate (Details) - USD ($)		12 Months Ended
	Dec. 22, 2017	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income (loss) before income taxes:
United States		$ (365,332,000)	$ (393,955,000)	$ (309,183,000)
Foreign		91,078,000	38,045,000	(39,906,000)
Loss before income tax		(274,254,000)	(355,910,000)	(349,089,000)
Current
Federal		0	0	0
State		0	0	6,000
Foreign		4,163,000	2,877,000	(100,000)
Deferred
Federal		(1,410,000)	(984,000)	0
State		(155,000)	(1,415,000)	0
Foreign		0	0	0
Income tax expense (benefit)		$ 2,598,000	$ 478,000	$ (94,000)
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate	(21.00%)	(21.00%)	(21.00%)	(21.00%)
State taxes, net of federal benefit		0.00%	0.00%	(4.00%)
Nondeductible IPR&D		0.00%	0.00%	6.00%
Contingent consideration		0.00%	0.00%	1.00%
Tax credits		(7.00%)	(16.00%)	(10.00%)
Impact of foreign operations		4.00%	9.00%	2.00%
Nondeductible executive compensation		2.00%	1.00%	0.00%
Nondeductible debt conversion		0.00%	(1.00%)	0.00%
Other		0.00%	(1.00%)	0.00%
Valuation allowance		23.00%	29.00%	26.00%
Net		1.00%	0.00%	0.00%
Deferred federal, state and local, tax expense (benefit)		$ (1,600,000)
Accrual for interest and penalties		0
Accrual for uncertain tax positions		$ 0

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The portion of earnings or loss from continuing operations before income taxes that is attributable to foreign operations, which is defined as Income or Loss generated from operations located outside the entity's country of domicile.

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount recognized for uncertainty in income taxes classified as current.

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Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

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