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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Deferred tax assets
Intellectual property	$ 68,209	$ 46,521
Amortization/depreciation	489	2,329
Research tax credit	182,651	141,669
Net operating loss carry forwards	305,876	286,850
Deferred reimbursements	1,912	2,230
Non-cash stock issue	17,553	19,058
Interest carry forward limitation	5,655	2,224
Lease liability	9,235	6,983
Other	10,855	13,921
Gross deferred tax assets	602,435	521,785
Deferred tax liabilities
Business acquisition	(4,937)	(5,051)
Royalty payable	(68,209)	(46,521)
Convertible notes	(94)	(653)
Advanced R&D payments	(1,776)	(2,611)
Right of use asset	(3,420)	(5,643)
Total net deferred tax assets	523,999	461,306
Less: valuation allowance	(528,895)	(466,357)
Net deferred tax liability	(4,896)	$ (5,051)
Increase in the valuation allowance	$ 62,500

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