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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Operating activities    
Net loss $ (65,664) $ (88,948)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of debt discount and deferred financing 555 231
Depreciation and amortization 1,604 1,764
Stock-based compensation 20,354 12,596
Non-cash changes in the fair value of contingent consideration payable 471 931
Foreign currency remeasurement loss 2,846 10,662
Changes in operating assets and liabilities:    
Accounts receivable 839 (8,358)
Inventories 741 (251)
Prepaid expenses and other current assets 7,669 4,016
Accounts payable and accrued expenses (40,191) (35,251)
Other non-current assets and liabilities (1,578) (5,334)
Net cash used in operating activities (72,354) (107,942)
Investing activities    
Sale and redemption of marketable securities 163,680 106,140
Purchases of marketable securities (76,247) (12,088)
Capital expenditures (868) (806)
Net cash provided by investing activities 86,565 93,246
Financing activities    
Payment of finance leases (368) (21)
Purchase of vested restricted stock units (14,194) (7,543)
Proceeds from exercise of stock options 4,161 6,077
Proceeds from exercise of warrants 19,230 0
Net cash provided by (used in) financing activities 8,829 (1,487)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (1,153) (4,265)
Net increase(decrease) in cash, cash equivalents, and restricted cash at the end of the period 21,887 (20,448)
Cash, cash equivalents, and restricted cash at beginning of period 166,162 146,341
Cash, cash equivalents, and restricted cash at the end of period 188,049 125,893
Supplemental disclosures of cash flow information    
Tenant improvements paid through lease incentives 0 254
Cash paid during the period for interest 7,513 3,693
Capital expenditures unpaid at the end of period 188 589
Cash paid for taxes $ 2,472 $ 1,627