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Share-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2021

Share-based Payment Arrangement [Abstract]

Schedule of Fair Value of Options

The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:

			Three Months Ended June 30,												Six Months Ended June 30,
			2021						2020						2021						2020
Expected stock price volatility			65.5		%				74.9		%				66.4		%				75.2		%
Risk free interest rate			0.7		%				0.4		%				0.5		%				1.6		%
Expected life of options (years)			5.4						5.7						5.4						5.7
Expected annual dividend per share			$	—					$	—					$	—					$	—

Schedule of Stock Options Activity

A summary of the Company's stock options for the six months ended June 30, 2021 were as follows:

			Number of Shares						Weighted Average Exercise  Price						Weighted Average Remaining Years						Aggregate Intrinsic Value
			(in thousands)																		(in millions)
Options outstanding, December 31, 2020			14,032						$	9.54
Granted			2,453						$	18.54
Exercised			(945)						$	7.29
Forfeited			(524)						$	13.04
Expired			(54)						$	13.21
Options outstanding, June 30, 2021			14,962						$	11.02					6.6						$	15.1
Vested and unvested expected to vest, June 30, 2021			13,586						$	10.80					6.4						$	15.0
Exercisable at June 30, 2021			9,074						$	9.34					5.3						$	14.8

Schedule of Non-Vested RSU Activity under the Plan

A summary of non-vested RSU activity under the Plan for the six months ended June 30, 2021 is as follows:

			Number of Shares						Weighted Average Grant Date Fair Value						Weighted  Average Remaining  Years						Aggregate Intrinsic Value
			(in thousands)																		(in millions)
Non-vested units as of December 31, 2020			7,080						$	11.35
Granted			2,451						$	18.89
Vested			(1,513)						$	16.81
Forfeited			(606)						$	13.77
Non-vested units as of June 30, 2021			7,412						$	13.96					2.5						$	71.5

Schedule of Equity Compensation Expenses

The following table summarizes information related to compensation expense recognized in the Consolidated Statements of Operations related to the equity awards:

						Three Months Ended June 30,												Six Months Ended June 30,
(in thousands)						2021						2020						2021						2020
Equity compensation expense recognized in:
Research and development expense						$	3,152					$	3,362					$	9,457					$	8,615
Selling, general, and administrative expense						8,584						5,046						22,633						12,389
Total equity compensation expense						$	11,736					$	8,408					$	32,090					$	21,004

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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