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Share-Based Compensation - Expense Summary (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 11,841 $ 15,908 $ 43,931 $ 36,912
Research and development expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense 3,775 8,626 13,232 17,241
Selling, general, and administrative expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Total equity compensation expense $ 8,066 $ 7,282 $ 30,699 $ 19,671