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Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019   255,417,869        
Beginning balance at Dec. 31, 2019 $ 476,425 $ 2,598 $ 2,227,225 $ 12,387 $ 2,825 $ (1,768,610)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares)   2,832,310        
Stock options exercised, net 20,028 $ 28 20,000      
Employee withholding taxes related to restricted stock unit vesting (in shares)   1,350,471        
Employee withholding taxes related to restricted stock unit vesting (9,340)   (9,340)      
Stock-based compensation 36,912   36,912      
Unrealized holding gain on available-for-sale securities (96)       (96)  
Foreign currency translation adjustment 1,791       1,791  
Net loss (205,451)         (205,451)
Ending balance (in shares) at Sep. 30, 2020   259,600,650        
Ending balance at Sep. 30, 2020 320,269 $ 2,626 2,274,797 12,387 4,520 (1,974,061)
Beginning balance (in shares) at Jun. 30, 2020   258,223,842        
Beginning balance at Jun. 30, 2020 360,953 $ 2,614 2,250,849 12,387 5,153 (1,910,050)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares)   1,223,075        
Stock options exercised, net 9,295 $ 12 9,283      
Employee withholding taxes related to restricted stock unit vesting (in shares)   153,733        
Employee withholding taxes related to restricted stock unit vesting (1,243)   (1,243)      
Stock-based compensation 15,908   15,908      
Unrealized holding gain on available-for-sale securities (344)       (344)  
Foreign currency translation adjustment (289)       (289)  
Net loss (64,011)         (64,011)
Ending balance (in shares) at Sep. 30, 2020   259,600,650        
Ending balance at Sep. 30, 2020 $ 320,269 $ 2,626 2,274,797 12,387 4,520 (1,974,061)
Beginning balance (in shares) at Dec. 31, 2020 262,063,461 262,063,461        
Beginning balance at Dec. 31, 2020 $ 286,380 $ 2,650 2,308,578 12,387 8,227 (2,045,462)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares) 1,193,000 1,171,279        
Stock options exercised, net $ 8,357 $ 12 8,345      
Employee withholding taxes related to restricted stock unit vesting (in shares)   1,026,337        
Employee withholding taxes related to restricted stock unit vesting (14,700)   (14,700)      
Stock-based compensation 43,931   43,931      
Warrants exercised (in shares)   2,554,999        
Warrants exercised 19,230 $ 26 31,591 (12,387)    
Equity component of the convertible notes (in shares)   472,356        
Equity component of the convertible notes 2,661 $ 5 2,656      
Common stock issued from equity financing and pre-funded warrants (in shares)   11,296,660        
Common stock issued from equity financing and pre-funded warrants 199,747 $ 112 199,552 83    
Unrealized holding gain on available-for-sale securities 1       1  
Foreign currency translation adjustment (1,795)       (1,795)  
Net loss $ (167,183)         (167,183)
Ending balance (in shares) at Sep. 30, 2021 278,585,092 278,585,092        
Ending balance at Sep. 30, 2021 $ 376,629 $ 2,805 2,579,953 83 6,433 (2,212,645)
Beginning balance (in shares) at Jun. 30, 2021   266,532,536        
Beginning balance at Jun. 30, 2021 213,910 $ 2,685 2,364,494 0 9,082 (2,162,351)
Increase (Decrease) in Stockholders' Equity            
Stock options exercised, net (in shares)   248,617        
Stock options exercised, net 1,696 $ 3 1,693      
Employee withholding taxes related to restricted stock unit vesting (in shares)   39,007        
Employee withholding taxes related to restricted stock unit vesting (262)   (262)      
Stock-based compensation 11,841   11,841      
Equity component of the convertible notes (in shares)   468,272        
Equity component of the convertible notes 2,640 $ 5 2,635      
Common stock issued from equity financing and pre-funded warrants (in shares)   11,296,660        
Common stock issued from equity financing and pre-funded warrants 199,747 $ 112 199,552 83    
Unrealized holding gain on available-for-sale securities (11)       (11)  
Foreign currency translation adjustment (2,638)       (2,638)  
Net loss $ (50,294)         (50,294)
Ending balance (in shares) at Sep. 30, 2021 278,585,092 278,585,092        
Ending balance at Sep. 30, 2021 $ 376,629 $ 2,805 $ 2,579,953 $ 83 $ 6,433 $ (2,212,645)