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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities    
Net loss $ (167,183) $ (205,451)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of debt discount and deferred financing 1,852 1,124
Depreciation and amortization 4,691 6,299
Stock-based compensation 43,931 36,912
Loss on extinguishment of debt 257 7,276
Non-cash changes in the fair value of contingent consideration payable 4,780 2,680
Foreign currency remeasurement loss (gain) 4,247 (1,084)
Changes in operating assets and liabilities:    
Accounts receivable (6,372) (10,845)
Inventories (3,022) 2,182
Prepaid expenses and other current assets 9,080 4,377
Accounts payable and accrued expenses (22,068) (23,424)
Other non-current assets and liabilities (2,170) (2,264)
Deferred reimbursements 0 (1,250)
Net cash used in operating activities (131,977) (183,468)
Investing activities    
Sale and redemption of marketable securities 342,343 272,679
Purchases of marketable securities (193,369) (261,322)
Capital expenditures (2,124) (2,160)
Net cash provided by investing activities 146,850 9,197
Financing activities    
Payment of long-term debt 0 (155,249)
Proceeds from long-term debt, net of issuance costs 0 385,929
Proceeds from issuance of common stock from equity financing and pre-funded warrants 199,750 0
Proceeds from warrants exercised 19,230 0
Payment of finance leases (460) (58)
Payments of employee withholding taxes related to restricted stock unit vesting (14,700) (9,340)
Proceeds from stock options exercised, net 8,357 20,028
Net cash provided by financing activities 212,177 241,310
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (4,141) 45
Net increase in cash, cash equivalents, and restricted cash at the end of the period 222,909 67,084
Cash, cash equivalents, and restricted cash at beginning of period 166,162 146,341
Cash, cash equivalents, and restricted cash at the end of period 389,071 213,425
Supplemental disclosures of cash flow information    
Tenant improvements paid through lease incentives 67 470
Cash paid during the period for interest 22,788 16,712
Capital expenditures unpaid at the end of period 327 265
Cash paid for taxes $ 9,854 $ 5,912