<SEC-DOCUMENT>0001104659-21-084168.txt : 20210622
<SEC-HEADER>0001104659-21-084168.hdr.sgml : 20210622
<ACCEPTANCE-DATETIME>20210622170107
ACCESSION NUMBER:		0001104659-21-084168
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20210622
DATE AS OF CHANGE:		20210622
EFFECTIVENESS DATE:		20210622

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMICUS THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001178879
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				200422823
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-257289
		FILM NUMBER:		211036069

	BUSINESS ADDRESS:	
		STREET 1:		3675 MARKET STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		(215) 921-7600

	MAIL ADDRESS:	
		STREET 1:		3675 MARKET STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMICUS THERAPEUTICS INC
		DATE OF NAME CHANGE:	20020729
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>tm2119601d2_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
on June 22, 2021.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>File No. 333- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, DC 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AMICUS THERAPEUTICS, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in Its Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 49%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>DELAWARE</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 49%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>71-0869350</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Incorporation or Organization)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3675 Market Street, Philadelphia, PA 19104<BR>
</B>(Address of Principal Executive Office)( Zip Code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN<BR>
</B>(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>John F. Crowley<BR>
Chief Executive Officer<BR>
Amicus Therapeutics, Inc.<BR>
3675 Market Street</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Philadelphia, PA 19104</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of Agent for Service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(215) 921-7600<BR>
</B>(Telephone Number for agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Copy to:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Scott R. Jones, Esquire<BR>
</B>Troutman Pepper Hamilton Sanders LLP<BR>
400 Berwyn Park<BR>
899 Cassatt Road<BR>
Berwyn, Pennsylvania 19312-1183<BR>
(610) 640-7800</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging
growth company&#8221; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 51%; padding: 0.5pt 0.5pt 0.5pt 72.25pt"><FONT STYLE="font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 48%; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.5pt 72.25pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Smaller reporting company <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 72.25pt 0.5pt 0.5pt"><FONT STYLE="font-size: 10pt">Emerging growth company <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt 0.5pt 9.25pt; text-indent: -9pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; padding: 0.5pt 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title Of Securities<BR>
To Be Registered</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount To<BR>
 Be<BR>
Registered (1)</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed <BR>
Maximum<BR>
Offering Price<BR>
Per Share (2)</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed <BR>
Maximum<BR>
Aggregate<BR>
Offering Price</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount Of<BR>
Registration<BR>
Fee</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; width: 46%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt 9.25pt; text-indent: -9pt"><FONT STYLE="font-size: 10pt">Common stock, par value $0.01 per share</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 10%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: right"><FONT STYLE="font-size: 10pt">7,000,000</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 13%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: right">9.88</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; vertical-align: bottom; width: 13%; padding: 0.25pt 0.25pt 0.5pt; text-align: right"><FONT STYLE="font-size: 10pt">69,160,000</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 10%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: right">7,545.36</TD>
    <TD STYLE="vertical-align: bottom; width: 1%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(1) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with Rule
416 under the Securities Act of 1933, as amended, this Registration Statement on Form S-8 shall be deemed to cover any additional shares
of common stock, par value $0.01 per share (&#8220;Common Stock&#8221;), of Amicus Therapeutics, Inc., a Delaware corporation (the &#8220;Registrant&#8221;),
which become issuable under the above-named plan by reason of any stock dividend, stock split, recapitalization or other similar transaction
effected without the receipt of consideration which results in an increase in the number of the outstanding shares of Common Stock of
the Registrant.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(2) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Estimated in accordance
with Rule 457(c) and Rule 457(h), solely for the purpose of calculating the amount of the registration fee, on the basis of the average
of the high and low prices of Common Stock as reported on the NASDAQ Global Market on June 18, 2021.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Registration Statement on Form S-8 is being
filed for the purpose of registering an additional 7,000,000 shares of Common Stock that were added to the shares authorized for issuance
under the Registrant&#8217;s Amended and Restated 2007 Equity Incentive Plan for which a Registration Statement on Form S-8 relating to
the same employee benefit plan is effective. Pursuant to General Instruction E to Form S-8, the contents of the Registration Statements
on Form S-8 (File Nos. 333-145305, 333-157219, 333-174900, 333-233153 and 333-243779) filed with the Securities and Exchange Commission
(the &#8220;Commission&#8221;) on <FONT STYLE="color: #0000EE"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307011217/y37940sv8.htm" STYLE="-sec-extract: exhibit">August 10, 2007</A></FONT>, <FONT STYLE="color: #0000EE"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000089322009000251/w72683sv8.htm" STYLE="-sec-extract: exhibit">February 10, 2009</A></FONT>,
<FONT STYLE="color: #0000EE"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012311059118/c18760sv8.htm" STYLE="-sec-extract: exhibit">June 15, 2011</A></FONT>, <FONT STYLE="color: #0000EE"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1s8.htm" STYLE="-sec-extract: exhibit">August 8, 2019</A></FONT>, and <FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465920092862/tm2026897d1_s8.htm" STYLE="-sec-extract: exhibit">August 11, 2020</A></FONT>, respectively, are incorporated herein by reference except to the extent supplemented, amended or superseded by the information
set forth herein. Only those items of Form S-8 containing new information not contained in the earlier registration statements are presented
herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following documents of the Registrant filed
with the Commission are incorporated by reference in this Registration Statement as of their respective dates:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font-size: 10pt; color: #0000EE">(a)</FONT></TD>
    <TD><A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1178879/000117887921000004/fold-20201231.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">The Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2020, filed with the Commission on March 1, 2021;</FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(b)</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s Definitive Proxy Statement on Schedule 14A, filed with the Commission on April 27, 2021;</FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000117887921000006/fold-20210331.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">(c)</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000117887921000006/fold-20210331.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">The Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended March 31, 2021 filed with the Commission on May 10, 2021;</FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font-size: 10pt">(d)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">The Registrant&#8217;s Current Reports on Form 8-K (other than portions thereof furnished under
    Item 2.02 or Item 7.01 of Form 8-K and exhibits accompanying such reports that are related to such items) filed on <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465921002681/tm212263d1_8k.htm" STYLE="-sec-extract: exhibit">January
    11, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465921013630/tm215748d1_8k.htm" STYLE="-sec-extract: exhibit">February
    8, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465921020661/tm216326d1_8k.htm" STYLE="-sec-extract: exhibit">February
    11, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001178879/000110465921059581/tm2114909d1_8k.htm" STYLE="-sec-extract: exhibit">May
    3, 2021</A>, <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1178879/000110465921077960/tm2119052d1_8k.htm" STYLE="-sec-extract: exhibit">June 8, 2021</A> and <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1178879/000110465921077960/tm2119052d1_8k.htm" STYLE="-sec-extract: exhibit">June 14, 2021</A>; and</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font-size: 10pt">(e)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">The description of the Common Stock contained in the <FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007844/y32191ae8va12b.htm" STYLE="-sec-extract: exhibit">Form 8-A filed with the Commission on May 23, 2007</A></FONT> pursuant to the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), including any amendment or report filed for the purpose of further updating such description.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">All documents subsequently filed by the Registrant
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment which indicates
that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated
by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; provided, however, that
documents or information deemed to have been furnished and not filed in accordance with Commission rules shall not be deemed incorporated
by reference into this Registration Statement. Any statement contained herein or in a document, all or a portion of which is incorporated
or deemed to be incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as
so modified or amended, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 7%; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><B>Exhibit<BR>
Number</B></FONT></TD>
    <TD STYLE="width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 6%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 83%; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(1)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000119312512085717/d299897dex31.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Restated Certificate of Incorporation of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(2)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465915044580/a15-13880_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.3</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(3)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465918039068/a18-15070_1ex3d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.4</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(4)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307006223/y32191a1exv3w4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Restated By-laws of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.5</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(5)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307007596/y32191a2exv4w1.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Specimen Stock Certificate evidencing shares of common stock</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307004755/y32191exv4w2.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">4.6</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307004755/y32191exv4w2.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(6)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000095012307004755/y32191exv4w2.txt" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Third Amended and Restated Investor Rights Agreement, dated as of September 13, 2006, as amended, by and among the Registrant and certain stockholders of the Registrant</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">5.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Opinion of Troutman Pepper Hamilton Sanders LLP</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">23.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex23-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">23.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="tm2119601d2_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Consent of Troutman Pepper Hamilton Sanders LLP (included in Exhibit 5.1)</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="#a_001"><FONT STYLE="font-size: 10pt; color: #0000EE">24.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="#a_001"><FONT STYLE="font-size: 10pt; color: #0000EE">Power of Attorney (included on the signature page)</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">99.1</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(7)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000114036121014545/nc10021408x1_def14a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">99.2</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(8)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465916164572/a16-23950_1ex10d1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Form of Performance-Based Restricted Stock Unit Award Agreement under the Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d5.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">99.3</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d5.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(9)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d5.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Form of Time-Based Restricted Stock Unit Award Agreement under the Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d6.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">99.4</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d6.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(10)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d6.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Form of Non-Qualified Stock Option Agreement (Domestic) under the Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d7.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">99.5</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d7.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">(11)</FONT></A></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1178879/000110465919044956/a19-16819_1ex99d7.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt; color: #0000EE">Form of Non-Qualified Stock Option Agreement (International) under the Amended and Restated 2007 Equity Incentive Plan</FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0%">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Annual Report on Form 10-K filed on February 28, 2012.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on June 10, 2015.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on June 8, 2018.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 3.4 to the Registrant&#8217;s Registration Statement on Form S-1/A (Registration No. 333-141700), as amended, originally filed with the Commission on April 27, 2007.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(5)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1/A (Registration No. 333-141700), filed with the SEC on May 17, 2007.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(6)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 4.2 to the Registrant&#8217;s Registration Statement on Form S-1 (Registration No. 333-141700), as amended, originally filed with the SEC on March 30, 2007).</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(7)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit A to the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed on April 27, 2021.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(8)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 10.1 to the Registrant&#8217;s Current Report on Form 8-K filed on December 30, 2016.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(9)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 99.5 to the Registrant&#8217;s Registration Statement on Form S-8 (Registration No. 333-233153) filed on August 8, 2019.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(10)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 99.6 to the Registrant&#8217;s Registration Statement on Form S-8 (Registration No. 333-233153) filed on August 8, 2019.</FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font-size: 10pt">(11)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Incorporated by reference to Exhibit 99.7 to the Registrant&#8217;s Registration Statement on Form S-8 (Registration No. 333-233153) filed on August 8, 2019.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_001"></A>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the city of Philadelphia, Commonwealth of Pennsylvania, on the 22nd day of June, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">AMICUS THERAPEUTICS, INC.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt">/s/ John F. Crowley</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 3%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="width: 42%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">John F. Crowley</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
    <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Chairman and Chief Executive Officer</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We, the undersigned officers and directors of Amicus
Therapeutics, Inc., hereby severally constitute and appoint John F. Crowley, Bradley L. Campbell, Daphne Quimi and Ellen S. Rosenberg,
and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names
in the capacities indicated below, the Registration Statement on Form S-8 filed herewith and any and all subsequent amendments to said
Registration Statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors
to enable Amicus Therapeutics, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the
Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any
of them, to said Registration Statement and any and all amendments thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities indicated
on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 34%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
    <TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 32%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
    <TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 32%; border-bottom: black 1pt solid; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ John F. Crowley</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chairman and Chief Executive Officer</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">John F. Crowley</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Daphne Quimi</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Daphne Quimi</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Principal Financial Officer)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Samantha Prout</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Global Controller</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Samantha Prout</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Principal Accounting Officer)</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Lynn D. Bleil</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Lynn D. Bleil</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Bradley L. Campbell</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Bradley L. Campbell</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Robert Essner</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Robert Essner</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt; width: 34%"><FONT STYLE="font-size: 10pt">/s/ Michael A. Kelly</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center; width: 32%"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center; width: 32%"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Michael A. Kelly</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Margaret G. McGlynn, R.Ph.</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Margaret G. McGlynn, R.Ph.</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Michael G. Raab</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Michael G. Raab</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Eiry W. Roberts, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Eiry W. Roberts</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Glenn P. Sblendorio</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Glenn P. Sblendorio</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Craig A. Wheeler</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Craig A. Wheeler</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt"><FONT STYLE="font-size: 10pt">/s/ Burke W. Whitman</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding: 0.5pt 0.5pt 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">June 22, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt 0.5pt 0.25pt"><FONT STYLE="font-size: 10pt">Burke W. Whitman</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; text-align: center">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>





</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>tm2119601d2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
  <TD STYLE="border-bottom: Black 1pt solid; text-align: left; width: 15pc"><P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Troutman Pepper Hamilton Sanders LLP</P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">400 Berwyn Park, 899 Cassatt Road</P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Berwyn, PA 19312-1183</P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">troutman.com</P><B>&nbsp;</B></TD>
  <TD STYLE="border-bottom: Black 1pt solid; text-align: right"><IMG SRC="tm2119601d2_ex5-1img001.jpg" ALT="">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
  <TD STYLE="text-align: left">&nbsp;</TD>
  <TD STYLE="text-align: right">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 5.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">June 22, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Amicus Therapeutics, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3675 Market Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Philadelphia, PA 19104</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
  <TD STYLE="text-align: center; padding-left: 10pt; width: 15%">Re:</TD>
  <TD STYLE="padding-left: 10pt; text-indent: -10pt"><U>Registration Statement on Form&nbsp;S-8</U></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 24.5pt">Reference is made to the
registration statement on Form&nbsp;S-8 (the &#8220;<B><I>Registration Statement</I></B>&#8221;) of Amicus Therapeutics, Inc., a Delaware
corporation (the &#8220;<B><I>Company</I></B>&#8221;), filed on the date hereof with the Securities and Exchange Commission (the &#8220;<B><I>Commission</I></B>&#8221;),
under the Securities Act of 1933, as amended (the &#8220;<B><I>Act</I></B>&#8221;).&nbsp; The Registration Statement covers an aggregate
of 7,000,000 shares (the &#8220;<B><I>Shares</I></B>&#8221;), of the Company&#8217;s common stock, par value $0.001 per share (&#8220;<B><I>Common
Stock</I></B>&#8221;) under the Company&#8217;s Amended and Restated 2007 Equity Incentive Plan (as amended, the &#8220;<B><I>Plan</I></B>&#8221;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 24.5pt">We have examined the Registration
Statement, including the exhibits thereto, the originals or copies, certified or otherwise identified to our satisfaction, of the Company&#8217;s
Restated Certificate of Incorporation, as amended, the Company&#8217;s Restated Bylaws, the Plan and such other agreements, instruments
and documents as we have deemed appropriate in rendering this opinion.&nbsp; As to matters of fact, we have relied on certain representations
of officers of the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 24.5pt">In rendering this opinion,
we have assumed the genuineness and authenticity of all signatures on original documents; the legal capacity of all natural persons; the
authenticity of all documents submitted to us as originals; the conformity to originals of all documents submitted to us as certified
or photocopies; the accuracy and completeness of all documents and records reviewed by us; the accuracy, completeness and authenticity
of certificates issued by any governmental official, office or agency and the absence of change in the information contained therein from
the effective date of any such certificate; and the due authorization, execution and delivery of all documents where authorization, execution
and delivery are prerequisites to the effectiveness of such documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 27pt">We express no opinion herein
as to the law of any state or jurisdiction other than the laws of the States of Delaware, including statutory provisions and all applicable
provisions of the Delaware Constitution and reported judicial decisions interpreting such laws of such states and the federal laws of
the United States of America. We assume no obligation to supplement this opinion if any applicable law changes after the date hereof or
if we become aware of any fact that might change the opinion expressed herein after the date hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 24.5pt">Based on the foregoing, we
are of the opinion that the Shares, when issued in accordance with the terms of the Plan, will be validly issued, fully paid and non-assessable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt"></P>

<!-- Field: Page; Sequence: 1 -->
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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; text-indent: 24.5pt"><IMG SRC="tm2119601d2_ex5-1img001.jpg" ALT=""></P>

<P STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 24.5pt">We hereby consent to the
filing of this opinion as an exhibit to the Registration Statement.&nbsp; In giving such consent, we do not thereby admit that we come
within the category of persons whose consent is required under Section&nbsp;7 of the Act or the rules&nbsp;or regulations of the Commission
thereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">Very truly yours,</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Troutman Pepper Hamilton</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Troutman Pepper Hamilton Sanders LLP</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>





</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>tm2119601d2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 23.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING
FIRM</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">We consent to the incorporation by reference in
this Registration Statement (Form S-8) pertaining to the Amended and Restated 2007 Equity Incentive Plan of Amicus Therapeutics, Inc.,
of our reports dated March 1, 2021, with respect to the consolidated financial statements of Amicus Therapeutics, Inc., and the effectiveness
of internal control over financial reporting of Amicus Therapeutics, Inc., included in its Annual Report (Form 10-K) for the year ended
December 31, 2020, filed with the Securities and Exchange Commission.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">/s/ Ernst &amp; Young LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Iselin, New Jersey</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">June 22, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>





</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>tm2119601d2_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
