Exhibit 99.2

 Exhibit 99.2 Full Year 2020 Financial Results Conference Call & Webcast March 1, 2021

Introduction 2 Forward-Looking Statements This presentation contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 relating to preclinical and clinical development of our product candidates, the timing and reporting of results from preclinical studies and clinical trials, the prospects and timing of the potential regulatory approval of our product candidates, commercialization plans, manufacturing and supply plans, financing plans, and the projected revenues and cash position for the Company. The inclusion of forward-looking statements should not be regarded as a representation by us that any of our plans will be achieved. Any or all of the forward-looking statements in this press release may turn out to be wrong and can be affected by inaccurate assumptions we might make or by known or unknown risks and uncertainties. For example, with respect to statements regarding the goals, progress, timing, and outcomes of discussions with regulatory authorities, and in particular the potential goals, progress, timing, and results of preclinical studies and clinical trials, and revenue goals, including as they are impacted by COVID-19 related disruption, are based on current information. The potential impact on operations and/or revenue from the COVID-19 pandemic is inherently unknown and cannot be predicted with confidence and may cause actual results and performance to differ materially from the statements in this release, including without limitation, because of the impact on general political and economic conditions, including as a result of efforts by governmental authorities to mitigate COVID-19, such as travel bans, shelter in place orders and third-party business closures and resource allocations, manufacturing and supply chain disruptions and limitations on patient access to commercial or clinical product or to treatment sites. In addition to the impact of the COVID-19 pandemic, actual results may differ materially from those set forth in this release due to the risks and uncertainties inherent in our business, including, without limitation: the potential that results of clinical or preclinical studies indicate that the product candidates are unsafe or ineffective; the potential that it may be difficult to enroll patients in our clinical trials; the potential that regulatory authorities, including the FDA, EMA, and PMDA, may not grant or may delay approval for our product candidates; the potential that we may not be successful in commercializing Galafold in Europe, UK, Japan, the US and other geographies or our other product candidates if and when approved; the potential that preclinical and clinical studies could be delayed because we identify serious side effects or other safety issues; the potential that we may not be able to manufacture or supply sufficient clinical or commercial products; and the potential that we will need additional funding to complete all of our studies, commercialization and manufacturing. Further, the results of earlier preclinical studies and/or clinical trials may not be predictive of future results. With respect to statements regarding corporate financial guidance and financial goals and the attainment of such goals and statements regarding projections of the Company's revenue and cash position, actual results may differ based on market factors and the Company's ability to execute its operational and budget plans. In addition, all forward-looking statements are subject to other risks detailed in our Annual Report on Form 10-K for the year ended December 31, 2020 to be filed today. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, and we undertake no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Non-GAAP Financial Measures In addition to financial information prepared in accordance with U.S. GAAP, this presentation also contains adjusted financial measures that we believe provide investors and management with supplemental information relating to operating performance and trends that facilitate comparisons between periods and with respect to projected information. These adjusted financial measures are non-GAAP measures and should be considered in addition to, but not as a substitute for, the information prepared in accordance with U.S. GAAP. We typically exclude certain GAAP items that management does not believe affect our basic operations and that do not meet the GAAP definition of unusual or non-recurring items. Other companies may define these measures in different ways. When we provide our expectation for non-GAAP operating expenses on a forward-looking basis, a reconciliation of the differences between the non-GAAP expectation and the corresponding GAAP measure generally is not available without unreasonable effort due to potentially high variability, complexity and low visibility as to the items that would be excluded from the GAAP measure in the relevant future period, such as unusual gains or losses. The variability of the excluded items may have a significant, and potentially unpredictable, impact on our future GAAP results.

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Introduction 4 PLATFORM & Glycobiology AT-GAA Phase 3 in Pompe Disease Two Clinical-Stage Gene Therapies $483.3M Cash as of 12/31/20 GLOBAL COMMERCIAL ORGANIZATION Robust R&D Engine Nearly 50+ Lysosomal Disorders and More Prevalent Rare Diseases EMPLYEES in 27untries Gene Therapy Protein Engineering World Class BIOLOGICS Capabilities A leading fully integrated, global rare disease biotechnology company

Introduction 5 2021 Key Strategic Priorities 1 2 3 4 5 Achieve double-digit Galafold growth and revenue $300M to $315M Report data from the AT-GAA Phase 3 PROPEL study and complete BLA and MAA filings for regulatory approvals Advance clinical studies, regulatory discussions and scientific data across industry leading gene therapy pipeline Further manufacturing capabilities and capacity to build world-class technical operations to support all gene therapy programs Maintain strong financial position

 Galafold® (migalastat) Global Launch… …taking a leadership role in the treatment of Fabry disease “We push ideas as far and as fast as possible” - Amicus Belief Statement

Galafold: Precision Medicine for Fabry Disease 7 Galafold Snapshot (as of December 31, 2020) One of the Most Successful $260.9M FY20 Galafold Revenue Rare Disease Launches $300M-315M FY21 Global Galafold Revenue 1,384 Amenable Mutations Included in the Label 348 nable Variants in U.S. Label Continue Expan in 2021 40+ Countries with Regulatory Approvals: including U.S., EU, Japan, and other Countries Galafold is indicated for adults with a confirmed diagnosis of Fabry Disease and an amenable mutation/variant. The most common adverse reactions reported with Galafold (≥10%) were headache, nasopharyngitis, urinary tract infection, nausea and pyrexia. For additional information about Galafold, including the full U.S. Prescribing Information, please visit https://www.amicusrx.com/pi/Galafold.pdf. For further important safety information for Galafold, including posology and method of administration, special warnings, drug interactions and adverse drug reactions, please see the European SmPC for Galafold available from the EMA website at www.ema.europa.eu. Galafold is an orally delivered small molecule precision medicine with a unique mechanism of action for Fabry patients with amenable variants that replaces the need for intravenously delivered ERT

Galafold: Precision Medicine for Fabry Disease 8 2020 Galafold Success Year-over-Year Sales Growth Quarterly Galafold Sales 2019 Operational Growth FX Impact 2020 3Q19 4Q19 1Q20 2Q20 3Q20 4Q20 2019 vs 2020 $70.9M $67M $62M $61M $55M $49M +1% $260.9M $182M +42% Growth remains strong with Q4 revenue of $70.9M and FY2020 revenue of $260.9M

Galafold: Precision Medicine for Fabry Disease 9 Galafold Global Commercial Momentum FY20 Strength Reflects Continued Strength with 1,400+ Treated Patients Strong patient demand and several new launch countries anticipated in 2021 Global mix of switch (60%) and previously untreated patients (40%) Continued growing prescriber base in the U.S. to nearly 200 physicians Continue to support diagnostic initiatives to drive a shorter pathway to diagnosis ▪ Co pliance and adherence 0% 10 success in renegotiatin ▪ Int national reimbursement agreements Time from PRF to shipment don to 21 days US ▪ US insurance re-authorizatio ne s ▪ Strong global demand supported by high compliance and adherence rates laying foundation for continued growth anticipated in 2021

Galafold: Precision Medicine for Fabry Disease 10 Galafold Geographic Growth Expect to add at least 5 additional countries in 2021 Expansion into multiple new markets throughout 2020 including: Poland, Iceland, Luxembourg, Argentina, Greece Regulatory approval in 40+ countries and commercial sales in 30+ of those today

Galafold: Precision Medicine for Fabry Disease 11 Outlook for 2021 • 2020 execution lays a solid foundation and global demand remains strong with continued growth anticipated in 2021 and beyond New Galafold patient additions slowed in Q4 due to COVID reemergence and resulting in increased lag time between patient identification and treatment initiation • • In 2021, project double-digit revenue growth with starts expected to be greater than in 2020 Expect higher patient adds and revenue growth in 2021 as COVID impact eases Continue to see >90% compliance and adherence net new patient • the second half of • rates globally Galafold Continues Strong Launch Performance & Cornerstone of Amicus Success Continued double-digit Galafold revenue growth to $300M-$315M in 2021

Galafold: Precision Medicine for Fabry Disease 12 Galafold Opportunity $1B+ Opportunity With inherent Fabry market growth and our work to improve screening and diagnosis, Galafold has the potential to drive $1B+ $500M+ Projected Revenue Peak annual revenue at peak $261M 2023 Durable growth and increasing investment in Fabry disease diagnosis drives longer-term market potential $91M 2020 Driven by: Market penetration in existing and new markets Continued uptake into diagnosed, untreated market 2018 Strong IP protection through orphan drug acts in U.S. and EU, as well as multiple patents Continued momentum across geographies 1st year of launch in major geographies

 AT-GAA: Next Potential Standard of Care for Pompe Disease “We encourage and embrace constant innovation” - Amicus Belief Statement

AT-GAA for Pompe Disease 1144 Unmet Need in Pompe Disease Today There is an initial positive effect on the most important outcome measures, however, a more limited long-term benefit of stabilization of the clinical course under ERT for many patients over a long period. Though, accordingto our data, this long-term therapeutic efficacy is and consecutively the support over time. As weakest for the lung capacity need of additional ventilatory respiratory insufficiency is the most frequent cause of death in Pompe disease, it is important to further improve this organ function in particular. The fast approval of novel therapeutic options is a great unmet need for Pompe patients.” Modified from Goodschmidt et. al., 2021, STIG study: real-world data of long-term outcomes of adults with Pompe disease under enzyme replacement therapy with alglucosidase alfa Natural history studies and publications in Pompe disease continue to highlight the unmet need and the continued decline on key measures of disease

AT-GAA for Pompe Disease 15 PROPEL Topline Results: Overall Population (n=122) 6MWD (m) FVC (% predicted) NOTES: Baseline is Mean (STDEV); CFBL is Mean LOCF (SE); P-values are nominal 2-sided; FVC data normally distributed and p–values are from ANCOVA. Results exclude one clinically implausible patient who used an investigational anabolic steroid ostarine (selective androgen receptor modulator) just prior to study start. 6MWD data not normally distributed and 6MWD p-value is for non-parametric ANCOVA; 6MWD parametric MMRM p-value was p=0.097. Treatment Baseline CFBL at Week 52 Difference P-Value AT-GAA (n=85) 70.7 (19.6) -0.9(0.7) +3.0 (1.2) p=0.023 Alglucosidase alfa (n=37) 69.7 (21.5) -4.0 (0.8) Treatment Baseline CFBL at Week 52 Difference P-Value AT-GAA (n=85) 357.9 (111.8) +20.8 (4.6) +13.6 (8.3) p=0.072 Alglucosidase alfa (n=37) 351.0 (121.3) +7.2 (6.6) 6MWD showed greater improvement with AT-GAA versus alglucosidase alfa but did not demonstrate statistical superiority; FVC demonstrated clinically significant improvement with AT-GAA over alglucosidase alfa

AT-GAA for Pompe Disease 16 PROPEL Topline Results ERT Experienced Population (n=95) 6MWD (m): Change from baseline (n=65, n=30) FVC (% predicted): Change from baseline (n=65, n=30) 2.0 1.5 30 1.0 25 0.5 0.0 20 -0.5 -1.0 -1.5 15 10 -2.0 -2.5 5 -3.0 -3.5 -4.0 0 -2 -4 -6 -8 -4.5 -5.0 Bas eline Week 12 Week 26 Visit Week 38 Week 52 LOCF Bas eline Week 12 Week 26 Visit Week 38 Week 52 LOCF NOTE: Baseline is Mean (STDEV); CFBL is Mean (SE); P-values are nominal 2-sided; FVC data normally distributed and p–values are from ANCOVA 6MWD data not normally distributed and 6MWD p-value is for non-parametric ANCOVA; 6MWD parametric MMRM p-value was p=0.078 Mean(SE) Actual Change in 6MWD (m) Mean(SE) Actual Change in Sitting % Predicted FVC Treatment:ATB200/AT2221Alglucos idas e Treatment: ATB200/AT2221 Alglucos idas e p=0.046 16.9 0.0 p=0.006 0.1 -4.0 ERT experienced patients treated with AT-GAA demonstrated improvements over time in 6MWD and stabilization over time in FVC versus alglucosidase alfa

AT-GAA for Pompe Disease 17 Primary, Key Secondary and Biomarker Endpoint Heat Map All Patients & ERT Experienced Patients Overall Population ERT Experienced Population Note: * Nominal P-value <0.05; based on LOCF means Alglucosidase alfa AT-GAA Motor Function 6MWD* GSGC* Pulmonary Function FVC* Muscle Strength Lower MMT PROs PROMIS-Physical PROMIS-Fatigue Biomarker Hex4* CK* Alglucosidase alfa AT-GAA Motor Function 6MWD GSGC* Pulmonary Function FVC* Muscle Strength Lower MMT PROs PROMIS-Physical PROMIS-Fatigue Biomarker Hex4* CK* Endpoints across motor function, pulmonary function, muscle strength, PROs and biomarkers favored AT-GAA over alglucosidase alfa in both the overall and ERT experienced populations

AT-GAA for Pompe Disease 18 Post Hoc Non-Inferiority Analyses p-value NOTE1: 6MWD results are based on MMRM analysis using observed cases and FV results are based on ANCOVA using LOCF. NOTE2: As Lumizyme did not show statistical significance versus placebo for 6MWD, the NI margins were not statistically justified. Results exclude one clinically implausible patient who used an investigational anabolic steroid ostarine (selective androgen receptor modulator) just prior to study start. Parameter Non-Inferiority Margin 1-sided 6MWD 15 meters 0.0004 10 meters 0.0026 5 meters 0.0127 3 meters 0.0224 % predicted FVC 1.1% 0.0008 Post hoc non-inferiority analyses of 6MWD and FVC are highly statistically significant

AT-GAA for Pompe Disease 19 AT-GAA: Key Takeaways • • Rolling BLA submission expected to complete in Q2 Other key regulatory submissions for approval throughout 2021 including MAA in Europe Potential for early approval under EAMS framework with Priority Innovative Medicines Designation in UK 150+ patients worldwide now being treated with AT-GAA including adults, adolescents and infants Pediatric study for Pompe patients aged 12 to <18 with late-onset Pompe disease ongoing Clinical study for Pompe patients with infantile onset disease expected to begin this year Expanded access program for Pompe infantile patients and adult-onset patients open and has enrolled multiple patients with Pompe.Further expanded access for all Pompe patients being considered. • • • • • AT-GAA for Pompe Advances Toward Approval

 Next Generation Gene Therapy Platform “We have a duty to obsolete our own technologies” - Amicus Belief Statement

Next Generation Gene Therapy Platform 21 *Exclusive license from Ultragenyx for Japanese rights to Mepsevii™, investigator-sponsored trial in Japan underway DISCOVERY PRECLINICAL PHASE 1/2 PHASE 3 REGULATORY COMMERCIAL Fabry Franchise Galafold®(migalastat) Monotherapy Fabry Gene Therapy PENN Pompe Franchise AT-GAA (Novel ERT + Enzyme Stabilizer) Pompe Gene Therapy PENN Batten Franchise – Gene Therapies CLN6 Batten Disease NCH CLN3 Batten Disease NCH CLN1 Batten Disease PENN Next Generation Research Programs and CNS Gene Therapies LEGEND ODD - Orphan Drug Designation RPD - Rare Pediatric Disease Designation PRIME - Priority Medicines Designation BTD - Breakthrough Therapy Designation CDKL5 Deficiency Disorder GTx / ERT PENN Angelman Syndrome PENN Others NCH / PENN MPS Franchise Mepsevii™ (vestronidase alfa) (Japan Only)* Next Generation MPSIIIA PENN MPSIIIB PENN ODD RPD ODD RPD PRIME ODD BTD ODD

Next Generation Gene Therapy Platform 22 CLN3 Batten AT-GTX-502 Disease Gene Therapy UBDRS=Unified Batten Disease Rating Scale. a Scheduled month 12 in-person UBDRS assessment was impacted by the COVID-19 pandemic. •Batten disease is a group of disorders known as neuronal ceroid lipofuscinoses (NCLs) •Mutation in one of 13 different CLN genes leads to neuronal lysosomal dysfunction •CLN3 Batten disease is one of the most common neurodegenerative disorders affecting children leading to blindness, motor impairment, learning difficulties, epilepsy and, ultimately, premature death •UBDRS-physical is the key efficacy endpoint for this study in CLN3 Batten assessing gross and fine motor function, vision and speech Low-Dose Cohort (n=3) Compared with Patients in the Natural History Study (n=82) Early clinical data suggest early signs of disease stabilization compared to natural history; plan to submit IND for next clinical study in 2H2021

 Financial Summary “We are business led and science driven” - Amicus Belief Statement

Financial Summary 24 2020 Select Financial Results (in thousands, except per share data) Dec. 31, 2020 Dec. 31, 2019 Product Revenue $260,886 $182,237 Cost of Goods Sold 31,044 21,963 R&D Expense 308,443 286,378 SG&A Expense 156,407 169,861 Changes in Fair Value of Contingent Consideration 3,144 3,297 Depreciation and Amortization 8,846 4,775 Loss from Operations (246,998) (304,037) Loss on Extinguishment of Debt (7,276) - Income Tax (Expense) Benefit (2,598) (478) Net Loss (276,852) (356,388) Net Loss Per Share (1.07) (1.48) 2020 revenue of $260.9M from global Galafold sales

Financial Summary 25 Financial Outlook: Key Takeaways • Galafold revenue in 2020 was $260.9 million, exceeding the Company’s guidance • 2020 Non-GAAP Operating Expenses of $415.7M in line with guidance of $410 million to $420 million • Non-GAAP operating expense guidance for 2021 is expected to remain flat at $410 million to $420 million – Driven by disciplined expense management and continued investment in the global Galafold launch, AT-GAA clinical studies and advancing our gene therapy pipeline • Current cash position is sufficient to achieve self-sustainability without the need for future dilutive financing

 Closing Remarks “We are business led and science driven” - Amicus Belief Statement

 ThankYou “Our passion for making a difference unites us” -Amicus Belief Statement

 Appendix

Amicus Therapeutics, Inc. Reconciliation ofNon-GAAP Financial i\•leasures (in thousands) December31 2020 s476,840 2019 2018 s Total operating expenses - as reported GAAP Research and d evelopment: Share-based compensation Asset acquisition related expenses for in- processR&D Selling, general and administrative: Share-based compensation Changes in fair value of contingent consideration payable Depreciation and amortization Total operating expense adjustments to reported GAAP Total ope.rating expenses -as adjusted $ 405,618 464,.311 20,817 17,575 11,740 100,000 28,334 3,144 17,520 3,300 26,855 3,297 8,846 4,775 4,216 61,141 52,502 136,776 $ $ $ 268,842 415,699 411,809 /vA-micus Therapeutics-