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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 | Dec. 31, 2020
Deferred tax assets |  |
Intellectual property | $ 105,453 | $ 68,209
Amortization/depreciation | 277 | 489
Research tax credit | 205,095 | 182,651
Net operating loss carry forwards | 334,762 | 305,876
Deferred reimbursements | 1,587 | 1,912
Non-cash stock issue | 11,779 | 17,553
Interest carry forward limitation | 8,285 | 5,655
Lease liability | 9,105 | 9,235
Other | 15,884 | 10,855
Gross deferred tax assets | 692,227 | 602,435
Deferred tax liabilities |  |
Business acquisition | (4,930) | (4,937)
Royalty payable | (105,453) | (68,209)
Convertible notes | 0 | (94)
Advanced R&D payments | (1,802) | (1,776)
Right of use asset | (3,130) | (3,420)
Total net deferred tax assets | 576,912 | 523,999
Less: valuation allowance | (581,842) | (528,895)
Net deferred tax liability | (4,930) | $ (4,896)
Increase in the valuation allowance | $ (52,900) |

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