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Leases | 12 Months Ended
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Dec. 31, 2021
Leases [Abstract] |
Leases | Leases The Company currently has operating leases for office and research laboratory space, equipment, and vehicles under agreements expiring at various dates through 2044, which include renewal options on leases which the Company is reasonably certain to exercise. For the years ended December 31, 2021, and 2020, operating lease expense was $10.0 million and $11.1 million and variable lease expense was $2.1 million and $1.8 million, respectively. For the years ended December 31, 2021, and 2020, the Company paid $8.4 million and $9.6 million, respectively, for amounts included in the measurement of operating lease liabilities and recorded $0.3 million and $1.7 million, respectively, of right-of-use assets and $0.3 million and $0.5 million, respectively, of tenant improvements paid through lease incentives in exchange for new operating lease liabilities. Commitments under finance leases are not significant for the year ended December 31, 2021. Supplemental balance sheet information related to operating leases were as follows:
(in thousands, except year and discount rate amounts) |  | December 31, 2021 |  | December 31, 2020
Operating lease ROU assets, net |  | $ | 20,586 |  |  | $ | 23,296 |
Current portion of the operating lease liabilities |  | $ | 7,409 |  |  | $ | 6,872 |
Non-current portion of the operating lease liabilities |  | 43,363 |  |  | 45,604 |
Total operating lease liability |  | $ | 50,772 |  |  | $ | 52,476 |
Weighted-average remaining lease terms (years) |  | 19.6 |  | 19.8
Weighted-average discount rate |  | 13.1 | % |  | 13.0 | %
At December 31, 2021, the future minimum operating lease payments were as follows:
(in thousands) |  | Operating Lease
2022 |  | $ | 8,514 |
2023 |  | 8,622 |
2024 |  | 8,347 |
2025 |  | 8,304 |
2026 |  | 8,454 |
Thereafter |  | 145,948 |
Total lease payments |  | 188,189 |
Less lease incentives |  | (28,939) |
Less imputed interest |  | (108,478) |
Total operating lease liability |  | $ | 50,772 |
As of December 31, 2021, the Company has an additional operating lease for office space that has not yet commenced, with minimum lease payments of $15.1 million. This operating lease commenced during the first quarter of 2022 with a lease term of ten years.

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- Definition The entire disclosure for operating leases of lessee. Includes, but is not limited to, description of operating lease and maturity analysis of operating lease liability. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -URI http://asc.fasb.org/subtopic&trid=77888251 + Details
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