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Collaborative Agreements (Details) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Oct. 31, 2018 USD ($) | Nov. 30, 2013 USD ($) market | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Collaborative Agreements |  |  |  |  |
Net product sales |  |  | $ 305,514 | $ 260,886 | $ 182,237
Deferred reimbursements |  |  | 5,906 | 7,406 |
Accrued expenses and other current liabilities |  |  | 98,153 | $ 96,841 |
Collaborative Arrangements |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Conditional aggregate payments per indication | $ 88,000 |  |  |  |
Discovery program fee | $ 10,000 |  |  |  |
Term of agreement | 5 years |  |  |  |
Collaborative Arrangements | GSK |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Payments for collaborative agreement |  |  | 1,500 |  |
Revised Agreement | GSK |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Potential milestone payments upon achievement of post-approval and sales-based milestones |  | $ 40,000 |  |  |
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | market |  | 8 |  |  |
Net product sales |  |  | 25,400 |  |
Deferred reimbursements |  |  | 7,400 |  |
Accrued expenses and other current liabilities |  |  | $ 4,500 |  |

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