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Stockholders' Equity - Common Stock and Warrants (Details) | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2021 USD ($) $ / shares shares | Mar. 31, 2019 USD ($) $ / shares shares | Sep. 30, 2021 USD ($) $ / shares shares | Mar. 31, 2021 USD ($) $ / shares shares | Sep. 30, 2019 USD ($) shares | Jun. 30, 2019 USD ($) $ / shares shares | Mar. 31, 2019 USD ($) $ / shares | Dec. 31, 2021 USD ($) vote $ / shares shares | Dec. 31, 2020 USD ($) $ / shares shares | Dec. 31, 2019 USD ($) shares
Convertible Debt |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized (in shares) | shares |  |  |  |  |  |  |  | 500,000,000 | 500,000,000 |
Voting right for each share held, number | vote |  |  |  |  |  |  |  | 1 |  |
Stock issued from equity financing (in shares) | shares |  |  |  |  |  | 18,700,000 |  |  |  |
Gross cash proceeds from warrant exercises |  | $ 800,000 |  | $ 19,200,000 |  |  |  | $ 19,230,000 | $ 0 | $ 812,000
Equity component of the convertible notes |  |  |  |  |  |  |  | $ 2,661,000 |  | 215,476,000
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  |  |  |  | $ 189,000,000 |  | $ 0 | $ 0 | 188,994,000
Contingent consideration, milestone payment |  |  |  |  |  |  | $ 9,000,000 |  |  |
Milestone payment, stock issued as consideration |  |  |  |  |  |  | 771,804 |  |  |
Stock issued for contingent consideration |  |  |  |  |  |  |  |  |  | 9,316,000
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs | $ 199,800,000 |  |  |  |  |  |  | $ 199,750,000 | $ 0 | $ 0
Convertible Notes |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  | $ 0.01 |  |  |  |
2016 Convertible Notes | Convertible Notes |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Debt conversion, converted instrument, amount |  |  | $ 2,800,000 |  | $ 247,200,000 |  |  |  |  |
Underwritten Offering |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued (in dollars per share) | $ / shares |  |  |  |  |  | $ 10.75 |  |  |  |
Private Placement |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Number of common shares called by warrants (in shares) | shares | 8,349,705 |  | 8,349,705 |  |  |  |  |  |  |
Stock issued (in dollars per share) | $ / shares | $ 10.18 |  | $ 10.18 |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares | $ 0.01 |  | $ 0.01 |  |  |  |  |  |  |
Stock Exercises at $7.98 |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares |  |  |  | $ 7.98 |  |  |  |  |  |
Stock Exercises at $7.06 |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares |  |  |  | $ 7.06 |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares | 11,296,660 |  |  |  |  |  |  |  |  | 18,720,930
Equity component of the convertible notes (in shares) | shares |  |  | 472,356 |  | 44,000,000 |  |  |  |  | 43,995,139
Equity component of the convertible notes |  |  | $ 5,000 |  | $ 440,000 |  |  |  |  |
Stock issued for contingent consideration |  |  |  |  |  |  | 8,000 |  |  |
Additional Paid-In Capital |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Equity component of the convertible notes |  |  | $ 2,656,000 |  | $ 215,036,000 |  |  |  |  |
Stock issued for contingent consideration |  |  |  |  |  |  | $ 9,308,000 |  |  |
Additional Paid-In Capital | Convertible Notes |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Equity component of the convertible notes |  |  |  |  |  |  |  |  |  | $ 215,000,000
Common Stock |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares |  | $ 7.98 |  |  |  |  | $ 7.98 |  |  |
Warrants |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  | 101,787 |  |  |  |  |  |  |  |
Warrants | Private Placement |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued (in dollars per share) | $ / shares | $ 10.17 |  | $ 10.17 |  |  |  |  |  |  |
Warrants | Stock Exercises at $7.98 |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  |  |  | 1,294,999 |  |  |  |  |  |
Warrants | Stock Exercises at $7.06 |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Stock issued from equity financing (in shares) | shares |  |  |  | 1,260,000 |  |  |  |  |  |

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