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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net loss | $ (250,460) | $ (276,852) | $ (356,388)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Amortization of debt discount and deferred financing | 2,490 | 1,794 | 2,546
Depreciation and amortization | 6,209 | 8,846 | 4,775
Stock-based compensation | 57,838 | 49,151 | 44,430
Loss on exchange of convertible notes | 0 | 0 | 40,624
Loss on extinguishment of debt | 257 | 7,276 | 0
Non-cash changes in the fair value of contingent consideration payable | 6,514 | 3,144 | 3,297
Foreign currency remeasurement loss | 3,565 | 5,471 | 254
Non-cash deferred taxes | 34 | (155) | (1,415)
Other | 0 | 99 | (149)
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (8,189) | (11,219) | (11,114)
Inventories | (7,790) | (4,639) | (5,114)
Prepaid expenses and other current assets | (5,919) | (8,766) | (3,287)
Accounts payable, accrued expenses, and other current liabilities | 7,430 | (10,610) | 46,742
Other non-current assets and liabilities | (2,617) | 4,420 | (10,117)
Deferred reimbursements | (1,500) | (1,250) | (5,500)
Payment of contingent consideration | (10,353) | 0 | 0
Net cash used in operating activities | (202,491) | (233,290) | (250,416)
Investing activities |  |  |
Sale and redemption of marketable securities | 424,043 | 354,826 | 499,047
Purchases of marketable securities | (341,398) | (365,178) | (383,882)
Capital expenditures | (3,884) | (3,227) | (20,012)
Net cash provided by (used in) investing activities | 78,761 | (13,579) | 95,153
Financing activities |  |  |
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs | 199,750 | 0 | 0
Proceeds from issuance of common stock, net of issuance costs | 0 | 0 | 188,994
Payment of long-term debt | 0 | (155,249) | 0
Proceeds from long-term debt, net of issuance costs | 0 | 385,929 | 0
Payment of finance leases | (479) | (76) | (420)
Payments of employee withholding taxes related to restricted stock unit vesting | (15,009) | (10,028) | (3,235)
Proceeds from termination of capped call confirmations | 0 | 0 | 19,875
Proceeds from stock options exercised, net | 10,228 | 42,282 | 11,476
Proceeds from warrants exercised, net | 19,230 | 0 | 812
Payment of contingent consideration | (1,647) | 0 | 0
Net cash provided by financing activities | 212,073 | 262,858 | 217,502
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (5,049) | 3,830 | 1,729
Net increase in cash, cash equivalents, and restricted cash | 83,294 | 19,819 | 63,968
Cash, cash equivalents, and restricted cash at the beginning of the year | 166,162 | 146,343 | 82,375
Cash, cash equivalents, and restricted cash at the end of the year | 249,456 | 166,162 | 146,343
Supplemental disclosures of cash flow information |  |  |
Tenant improvements paid through lease incentive | 300 | 470 | 19,388
Cash paid during the period for interest | 30,468 | 24,683 | 16,966
Contingent consideration paid in shares | 0 | 0 | 9,316
Capital expenditures unpaid at the end of period | 1,448 | 985 | 1,865
Cash paid for taxes | $ 20,032 | $ 10,371 | $ 691

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