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Description of Business (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2021 | Mar. 31, 2019 | Jun. 30, 2019 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Debt Instrument [Line Items] |  |  |  |  |  |
Stock issued from equity financing (in shares) |  |  | 18,700,000 |  |  |
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs | $ 199,800 |  |  | $ 199,750 | $ 0 | $ 0
Accumulated deficit |  |  |  | $ 2,295,922 | $ 2,045,462 |
Warrants |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Stock issued from equity financing (in shares) |  | 101,787 |  |  |  |
Private Placement |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Stock issued (in dollars per share) | $ 10.18 |  |  |  |  |
Number of common shares called by warrants (in shares) | 8,349,705 |  |  |  |  |
Private Placement | Warrants |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Stock issued (in dollars per share) | $ 10.17 |  |  |  |  |
Common Stock |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Stock issued from equity financing (in shares) | 11,296,660 |  |  |  |  | 18,720,930

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