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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Schedule of loss before Income Taxes | For financial reporting purposes, income (loss) before income taxes includes the following components:
|  | Years Ended December 31,
(in thousands) |  | 2021 |  | 2020 |  | 2019
United States |  | $ | (333,571) |  |  | $ | (365,332) |  |  | $ | (393,955) |
Foreign |  | 92,017 |  |  | 91,078 |  |  | 38,045 |
Total |  | $ | (241,554) |  |  | $ | (274,254) |  |  | $ | (355,910) |
Schedule of Income Tax Expense (Benefit) | Following were the components of income tax expense (benefit) for the years ended December 31, 2021, 2020, and 2019:
|  | Years Ended December 31,
(in thousands) |  | 2021 |  | 2020 |  | 2019
Current |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
State |  | — |  |  | — |  |  | — |
Foreign |  | 8,857 |  |  | 4,163 |  |  | 2,877 |
Deferred |  |  |  |  |  |
Federal |  | 15 |  |  | (1,410) |  |  | (984) |
State |  | 34 |  |  | (155) |  |  | (1,415) |
Foreign |  | — |  |  | — |  |  | — |
Total |  | $ | 8,906 |  |  | $ | 2,598 |  |  | $ | 478 |
Schedule of Reconciliation of the Statutory Tax Rates and the Effective Tax Rates | A reconciliation of the statutory tax rates and the effective tax rates for the years ended December 31, 2021, 2020, and 2019 are as follows:
|  | Years Ended December 31,
|  | 2021 |  | 2020 |  | 2019
Statutory rate |  | (21) | % |  | (21) | % |  | (21) | %
State taxes, net of federal benefit |  | — |  |  | — |  |  | — |
Nondeductible IPR&D |  | — |  |  | — |  |  | — |
Contingent consideration |  | — |  |  | — |  |  | — |
Tax credits |  | (9) |  |  | (7) |  |  | (16) |
Impact of foreign operations |  | 3 |  |  | 4 |  |  | 9 |
Nondeductible executive compensation |  | 2 |  |  | 2 |  |  | 1 |
Nondeductible debt conversion |  | — |  |  | — |  |  | (1) |
Other |  | 1 |  |  | — |  |  | (1) |
Valuation allowance |  | 28 |  |  | 23 |  |  | 29 |
Net |  | 4 | % |  | 1 | % |  | — | %
Schedule of Significant Components of the Deferred Tax Assets and Liabilities | The significant components of the deferred tax assets and liabilities are as follows:
|  | Years Ended December 31,
(in thousands) |  | 2021 |  | 2020
Deferred tax assets |  |  |  |
Intellectual property |  | $ | 105,453 |  |  | $ | 68,209 |
Amortization/depreciation |  | 277 |  |  | 489 |
Research tax credit |  | 205,095 |  |  | 182,651 |
Net operating loss carry forwards |  | 334,762 |  |  | 305,876 |
Deferred reimbursements |  | 1,587 |  |  | 1,912 |
Non-cash stock issue |  | 11,779 |  |  | 17,553 |
Interest carry forward limitation |  | 8,285 |  |  | 5,655 |
Lease liability |  | 9,105 |  |  | 9,235 |
Other |  | 15,884 |  |  | 10,855 |
Gross deferred tax assets |  | 692,227 |  |  | 602,435 |
Deferred tax liabilities |  |  |  |
Business acquisition |  | (4,930) |  |  | (4,937) |
Royalty payable |  | (105,453) |  |  | (68,209) |
Convertible notes |  | — |  |  | (94) |
Advanced R&D payments |  | (1,802) |  |  | (1,776) |
Right of use asset |  | (3,130) |  |  | (3,420) |
Total net deferred tax assets |  | 576,912 |  |  | 523,999 |
Less: valuation allowance |  | (581,842) |  |  | (528,895) |
Net deferred tax liability |  | $ | (4,930) |  |  | $ | (4,896) |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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