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Description of Business (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended		3 Months Ended	12 Months Ended
	Sep. 30, 2021	Mar. 31, 2019	Jun. 30, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Debt Instrument [Line Items]
Stock issued from equity financing (in shares)			18,700,000
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs	$ 199,800			$ 199,750	$ 0	$ 0
Accumulated deficit				$ 2,295,922	$ 2,045,462
Warrants
Debt Instrument [Line Items]
Stock issued from equity financing (in shares)		101,787
Private Placement
Debt Instrument [Line Items]
Stock issued (in dollars per share)	$ 10.18
Number of common shares called by warrants (in shares)	8,349,705
Private Placement | Warrants
Debt Instrument [Line Items]
Stock issued (in dollars per share)	$ 10.17
Common Stock
Debt Instrument [Line Items]
Stock issued from equity financing (in shares)	11,296,660					18,720,930

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