XML 61 R41.htm IDEA: XBRL DOCUMENT v3.22.0.1
Summary of Significant Accounting Policies - Revenue by Geographical Area (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Disaggregation of Revenue [Line Items]      
Net product sales $ 305,514 $ 260,886 $ 182,237
U.S.      
Disaggregation of Revenue [Line Items]      
Net product sales 95,387 80,046 52,478
Ex-U.S.      
Disaggregation of Revenue [Line Items]      
Net product sales $ 210,127 $ 180,840 $ 129,759