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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Statement [Abstract]      
Net product sales $ 305,514 $ 260,886 $ 182,237
Cost of goods sold 34,466 31,044 21,963
Gross profit 271,048 229,842 160,274
Operating expenses:      
Research and development 272,049 308,443 286,378
Selling, general, and administrative 192,710 156,407 169,861
Changes in fair value of contingent consideration payable 6,514 3,144 3,297
Depreciation and amortization 6,209 8,846 4,775
Total operating expenses 477,482 476,840 464,311
Loss from operations (206,434) (246,998) (304,037)
Other (expense) income:      
Interest income 509 3,226 10,249
Interest expense (32,471) (22,425) (18,872)
Loss on exchange of convertible notes 0 0 (40,624)
Loss on extinguishment of debt (257) (7,276) 0
Other expense (2,901) (781) (2,626)
Loss before income tax (241,554) (274,254) (355,910)
Income tax expense (8,906) (2,598) (478)
Net loss attributable to common stockholders $ (250,460) $ (276,852) $ (356,388)
Net loss attributable to common stockholders per common share - basic (in dollars per share) $ (0.92) $ (1.07) $ (1.48)
Net loss attributable to common stockholders per common share - diluted (in dollars per share) $ (0.92) $ (1.07) $ (1.48)
Weighted-average common shares outstanding - basic (in shares) 271,421,986 258,867,380 240,421,001
Weighted-average common shares outstanding - diluted (in shares) 271,421,986 258,867,380 240,421,001