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Stockholders' Equity - Common Stock and Warrants (Details)	1 Months Ended		3 Months Ended					12 Months Ended
	Sep. 30, 2021 USD ($) $ / shares shares	Mar. 31, 2019 USD ($) $ / shares shares	Sep. 30, 2021 USD ($) $ / shares shares	Mar. 31, 2021 USD ($) $ / shares shares	Sep. 30, 2019 USD ($) shares	Jun. 30, 2019 USD ($) $ / shares shares	Mar. 31, 2019 USD ($) $ / shares	Dec. 31, 2021 USD ($) vote $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 USD ($) shares
Convertible Debt
Common stock, shares authorized (in shares) | shares								500,000,000	500,000,000
Voting right for each share held, number | vote								1
Stock issued from equity financing (in shares) | shares						18,700,000
Gross cash proceeds from warrant exercises		$ 800,000		$ 19,200,000				$ 19,230,000	$ 0	$ 812,000
Equity component of the convertible notes								$ 2,661,000		215,476,000
Common stock, par value (in dollars per share) | $ / shares								$ 0.01	$ 0.01
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions						$ 189,000,000		$ 0	$ 0	188,994,000
Contingent consideration, milestone payment							$ 9,000,000
Milestone payment, stock issued as consideration							771,804
Stock issued for contingent consideration										9,316,000
Proceeds from issuance of common stock from equity financing and pre-funded warrants, net of issuance costs	$ 199,800,000							$ 199,750,000	$ 0	$ 0
Convertible Notes
Convertible Debt
Common stock, par value (in dollars per share) | $ / shares						$ 0.01
2016 Convertible Notes | Convertible Notes
Convertible Debt
Debt conversion, converted instrument, amount			$ 2,800,000		$ 247,200,000
Underwritten Offering
Convertible Debt
Stock issued (in dollars per share) | $ / shares						$ 10.75
Private Placement
Convertible Debt
Number of common shares called by warrants (in shares) | shares	8,349,705		8,349,705
Stock issued (in dollars per share) | $ / shares	$ 10.18		$ 10.18
Exercise price of warrants (in dollars per share) | $ / shares	$ 0.01		$ 0.01
Stock Exercises at $7.98
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares				$ 7.98
Stock Exercises at $7.06
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares				$ 7.06
Common Stock
Convertible Debt
Stock issued from equity financing (in shares) | shares	11,296,660									18,720,930
Equity component of the convertible notes (in shares) | shares			472,356		44,000,000					43,995,139
Equity component of the convertible notes			$ 5,000		$ 440,000
Stock issued for contingent consideration							8,000
Additional Paid-In Capital
Convertible Debt
Equity component of the convertible notes			$ 2,656,000		$ 215,036,000
Stock issued for contingent consideration							$ 9,308,000
Additional Paid-In Capital | Convertible Notes
Convertible Debt
Equity component of the convertible notes										$ 215,000,000
Common Stock
Convertible Debt
Exercise price of warrants (in dollars per share) | $ / shares		$ 7.98					$ 7.98
Warrants
Convertible Debt
Stock issued from equity financing (in shares) | shares		101,787
Warrants | Private Placement
Convertible Debt
Stock issued (in dollars per share) | $ / shares	$ 10.17		$ 10.17
Warrants | Stock Exercises at $7.98
Convertible Debt
Stock issued from equity financing (in shares) | shares				1,294,999
Warrants | Stock Exercises at $7.06
Convertible Debt
Stock issued from equity financing (in shares) | shares				1,260,000

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