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Income Taxes - Statutory Rate (Details) - USD ($)		12 Months Ended
	Dec. 22, 2017	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income (loss) before income taxes:
United States		$ (333,571,000)	$ (365,332,000)	$ (393,955,000)
Foreign		92,017,000	91,078,000	38,045,000
Loss before income tax		(241,554,000)	(274,254,000)	(355,910,000)
Current
Federal		0	0	0
State		0	0	0
Foreign		8,857,000	4,163,000	2,877,000
Deferred
Federal		15,000	(1,410,000)	(984,000)
State		34,000	(155,000)	(1,415,000)
Foreign		0	0	0
Income tax expense (benefit)		$ 8,906,000	$ 2,598,000	$ 478,000
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate	(21.00%)	(21.00%)	(21.00%)	(21.00%)
State taxes, net of federal benefit		0.00%	0.00%	0.00%
Nondeductible IPR&D		0.00%	0.00%	0.00%
Contingent consideration		0.00%	0.00%	0.00%
Tax credits		(9.00%)	(7.00%)	(16.00%)
Impact of foreign operations		3.00%	4.00%	9.00%
Nondeductible executive compensation		2.00%	2.00%	1.00%
Nondeductible debt conversion		0.00%	0.00%	(1.00%)
Other		1.00%	0.00%	(1.00%)
Valuation allowance		28.00%	23.00%	29.00%
Net		4.00%	1.00%	0.00%
Accrual for interest and penalties		$ 0

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No definition available.

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The portion of earnings or loss from continuing operations before income taxes that is attributable to foreign operations, which is defined as Income or Loss generated from operations located outside the entity's country of domicile.

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

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