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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets
Intellectual property	$ 105,453	$ 68,209
Amortization/depreciation	277	489
Research tax credit	205,095	182,651
Net operating loss carry forwards	334,762	305,876
Deferred reimbursements	1,587	1,912
Non-cash stock issue	11,779	17,553
Interest carry forward limitation	8,285	5,655
Lease liability	9,105	9,235
Other	15,884	10,855
Gross deferred tax assets	692,227	602,435
Deferred tax liabilities
Business acquisition	(4,930)	(4,937)
Royalty payable	(105,453)	(68,209)
Convertible notes	0	(94)
Advanced R&D payments	(1,802)	(1,776)
Right of use asset	(3,130)	(3,420)
Total net deferred tax assets	576,912	523,999
Less: valuation allowance	(581,842)	(528,895)
Net deferred tax liability	(4,930)	$ (4,896)
Increase in the valuation allowance	$ (52,900)

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